Painful peripheral neuropathy is a dose-limiting side effect of cisplatin treatment. Using a
murine model of cisplatin-induced hyperalgesia, we determined whether a PPARg synthetic …

Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse side effect of many anti-
cancer chemotherapeutic treatments. CIPN often causes neuropathic pain in extremities …

Background Neuropathic pain is observed in patients as chemotherapeutic oxaliplatin is
used to treat metastatic digestive tumors; however, the mechanisms responsible for …

Although platinum-based cancer chemotherapies produce painful peripheral neuropathy as
dose-limiting side effects, there are important differences in the pain syndromes produced by …

Oxaliplatin is a third-generation platinum-based chemotherapy drug that has gained
importance in the treatment of advanced metastatic colorectal cancer. Its dose-limiting side …

Neurotoxicity is the limiting side effect of the anticancer agent oxaliplatin. A tangled panel of
symptoms, sensory loss, paresthesia, dysesthesia, and pain may be disabling for patients …

Oxaliplatin, a platinum-based chemotherapeutic agent, has become a standard treatment for
advanced colorectal cancer. The dose-limiting toxicity of this compound is the development …

Oxaliplatin is a third-generation platinum-based chemotherapeutic drug. Although its
efficacy against colorectal cancer is well known, peripheral neuropathy that develops during …

Oxaliplatin is a commonly used drug to treat cancer, extending the rate of disease-free
survival by 20% in colorectal cancer. However, oxaliplatin induces a disabling form of …

Paclitaxel-induced neuropathic pain (PINP) is a dose-limiting side effect and is refractory to
widely used analgesic drugs. Previous studies have demonstrated a protective role of …