Since their discovery in cardiac myocytes more than 30 years ago, it has been recognized
that adenosine triphosphate-sensitive potassium (KATP) channels provide a very large …

Understanding the etiology of and development of appro-priate treatment for myocardial
ischemia and associated sudden cardiac death is a major goal of cardiovascular research …

Abstract ATP-sensitive potassium (K ATP) channels are abundantly expressed in the
myocardium. Although a definitive role for the channel remains elusive they have been …

The responses of the cardiac myocyte to a potentially injurious ischemic stress are multiple.
The opening of the ATP-sensitive K+ channels may constitute one such response. These …

We previously demonstrated that ATP-sensitive K+ channels (KATP) protect the guinea pig
myocardium against ischemia-reperfusion injury (Cole et al., Circ. Res. 69: 571-581, 1991) …

Our recent data demonstrate that activation of pmKATP channels polarizes the membrane of
cardiomyocytes and reduces Na+/Ca2+ exchange‐mediated Ca2+ overload. However, it is …

Congestive heart failure (CHF) is associated with intrinsic alterations of mitochondrial
oxidative phosphorylation which lead to increased myocardial cytosolic free ADP. ATP …

ATP-sensitive K+ (KATP) channels are present at high density in membranes of cardiac cells
where they regulate cardiac function during cellular metabolic impairment. KATP channels …

ATP is normally available in cells at millimolar concentrations and is" buffered" by
intracellular pools of other high-energy phosphates, such as creatine phosphate. Thus …

Shawn C Black and Benedict R Lucchesi he discovery of the adenosine triphosphate
dependent potassium channel (KATp channel; ATP sensitive T potassium channel) in …