Multiplex PCR Strategy for Rapid Identification of Structural Types and Variants of the mec Element in Methicillin-Resistant Staphylococcus aureus

DC Oliveira, H Lencastre - Antimicrobial agents and …, 2002 - Am Soc Microbiol
Full characterization of methicillin-resistant Staphylococcus aureus (MRSA) requires
definition of not only the bacterial genetic background but also the structure of the complex …

The Evolution of Pandemic Clones of Methicillin-Resistant Staphylococcus aureus: Identification of Two Ancestral Genetic Backgrounds and the Associated mec …

DC Oliveira, A Tomasz, H de Lencastre - Microbial Drug Resistance, 2001 - liebertpub.com
Previous surveillance studies carried out by our laboratories, primarily in Southern and
Eastern Europe, Latin America, and the United States, have characterized 3,067 methicillin …

Methicillin-resistant Staphylococcus aureus: molecular characterization, evolution, and epidemiology

S Lakhundi, K Zhang - Clinical microbiology reviews, 2018 - Am Soc Microbiol
Staphylococcus aureus, a major human pathogen, has a collection of virulence factors and
the ability to acquire resistance to most antibiotics. This ability is further augmented by …

Detection of the mec-A gene and phenotypic detection of resistance in Staphylococcus aureus isolates with borderline or low-level methicillin resistance

GE Bignardi, N Woodford, A Chapman… - Journal of …, 1996 - academic.oup.com
Eighty-three isolates of Staphylococcus aureus for which MICs of methicillin of 4–16 mg/L
had previously been recorded were tested for the presence of the mecA gene with a DNA …

Genetic Organization of the Downstream Region of themecA Element in Methicillin-Resistant Staphylococcus aureus Isolates Carrying Different Polymorphisms of …

DC Oliveira, SW Wu… - Antimicrobial Agents and …, 2000 - Am Soc Microbiol
We describe here the genetic organization of the mec element downstream of the mecA
gene in 34 different methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates …

Methicillin resistance in Staphylococcus isolates: the “mec alphabet” with specific consideration of mecC, a mec homolog associated with zoonotic S. aureus lineages

K Becker, B Ballhausen, R Köck… - International Journal of …, 2014 - Elsevier
Abstract Livestock-associated (LA) methicillin-resistant Staphylococcus aureus (MRSA)
have globally emerged during the past decade. In Europe, this was particularly due to the …

Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in Zürich, Switzerland (2003): Prevalence of Type IV SCCmec and a New SCCmec …

W Qi, M Ender, F O'Brien, A Imhof, C Ruef… - Journal of clinical …, 2005 - Am Soc Microbiol
The majority of methicillin-resistant Staphylococcus aureus (MRSA) isolates, recovered in
2003 at the Department of Medical Microbiology in Zürich, Switzerland, belonged to major …

Multiple mechanisms of methicillin resistance and improved methods for detection in clinical isolates of Staphylococcus aureus

H De Lencastre, AM Sa Figueiredo… - Antimicrobial Agents …, 1991 - Am Soc Microbiol
The mec gene of a number of clinical methicillin-resistant Staphylococcus aureus isolates
exhibiting a variety of heterogeneous expression modes was selectively inactivated by …

Methicillin-Resistance in Staphylococcus aureus Is Not Affected by the Overexpression in Trans of the mecA Gene Repressor: A Surprising Observation

DC Oliveira, H De Lencastre - PLoS One, 2011 - journals.plos.org
Methicillin-resistant Staphylococcus aureus (MRSA) is intrinsically cross-resistant to virtually
all β-lactam antibiotics. The central determinant for the MRSA phenotype is the mecA gene …

Structural Comparison of Three Types of Staphylococcal Cassette Chromosome mec Integrated in the Chromosome in Methicillin-Resistant Staphylococcus aureus

T Ito, Y Katayama, K Asada, N Mori… - Antimicrobial agents …, 2001 - Am Soc Microbiol
The β-lactam resistance gene mecA of Staphylococcus aureus is carried by a novel mobile
genetic element, designated staphylococcal cassette chromosome mec (SCC mec) …