Ebola virus VP24 binds karyopherin α1 and blocks STAT1 nuclear accumulation
SP Reid, LW Leung, AL Hartman, O Martinez… - Journal of …, 2006 - Am Soc Microbiol
Ebola virus (EBOV) infection blocks cellular production of alpha/beta interferon (IFN-α/β) and
the ability of cells to respond to IFN-α/β or IFN-γ. The EBOV VP35 protein has previously …
the ability of cells to respond to IFN-α/β or IFN-γ. The EBOV VP35 protein has previously …
Ebolavirus VP24 binding to karyopherins is required for inhibition of interferon signaling
M Mateo, SP Reid, LW Leung, CF Basler… - Journal of …, 2010 - Am Soc Microbiol
The Ebolavirus VP24 protein counteracts alpha/beta interferon (IFN-α/β) and IFN-γ signaling
by blocking the nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1) …
by blocking the nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1) …
Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKε and TBK-1
KC Prins, WB Cárdenas, CF Basler - Journal of virology, 2009 - Am Soc Microbiol
ABSTRACT The Ebola virus (EBOV) VP35 protein antagonizes the early antiviral alpha/beta
interferon (IFN-α/β) response. We previously demonstrated that VP35 inhibits the virus …
interferon (IFN-α/β) response. We previously demonstrated that VP35 inhibits the virus …
[HTML][HTML] Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1
During antiviral defense, interferon (IFN) signaling triggers nuclear transport of tyrosine-
phosphorylated STAT1 (PY-STAT1), which occurs via a subset of karyopherin alpha (KPNA) …
phosphorylated STAT1 (PY-STAT1), which occurs via a subset of karyopherin alpha (KPNA) …
Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin α proteins with activated STAT1
SP Reid, C Valmas, O Martinez, FM Sanchez… - Journal of …, 2007 - Am Soc Microbiol
The Zaire ebolavirus protein VP24 was previously demonstrated to inhibit alpha/beta
interferon (IFN-α/β)-and IFN-γ-induced nuclear accumulation of tyrosine-phosphorylated …
interferon (IFN-α/β)-and IFN-γ-induced nuclear accumulation of tyrosine-phosphorylated …
Knockdown of Ebola virus VP24 impairs viral nucleocapsid assembly and prevents virus replication
M Mateo, C Carbonnelle, MJ Martinez… - The Journal of …, 2011 - academic.oup.com
The structural protein VP24 of Ebola virus (EBOV) is a determinant of virulence in rodent
models and possesses an interferon antagonist function. In this study, we investigate the …
models and possesses an interferon antagonist function. In this study, we investigate the …
Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling
ABSTRACT The Ebola virus (EBOV) VP35 protein blocks the virus-induced phosphorylation
and activation of interferon regulatory factor 3 (IRF-3), a transcription factor critical for the …
and activation of interferon regulatory factor 3 (IRF-3), a transcription factor critical for the …
Ebola virus (EBOV) VP24 inhibits transcription and replication of the EBOV genome
S Watanabe, T Noda, P Halfmann… - The Journal of …, 2007 - academic.oup.com
The roles of Ebola virus (EBOV) VP24 in nucleocapsid (NC) formation and the effect of VP24
on transcription and replication of the viral genome during NC formation remain unknown …
on transcription and replication of the viral genome during NC formation remain unknown …
Evasion of interferon responses by Ebola and Marburg viruses
CF Basler, GK Amarasinghe - Journal of Interferon & Cytokine …, 2009 - liebertpub.com
The filoviruses, Ebola virus (EBOV) and Marburg virus (MARV), cause frequently lethal viral
hemorrhagic fever. These infections induce potent cytokine production, yet these host …
hemorrhagic fever. These infections induce potent cytokine production, yet these host …
[HTML][HTML] The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold
APP Zhang, ZA Bornholdt, T Liu, DM Abelson… - PLoS …, 2012 - journals.plos.org
Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are
characterized by early suppression of the host innate immune system. One of the proteins …
characterized by early suppression of the host innate immune system. One of the proteins …