Ebola virus (EBOV) infection blocks cellular production of alpha/beta interferon (IFN-α/β) and
the ability of cells to respond to IFN-α/β or IFN-γ. The EBOV VP35 protein has previously …

The Ebolavirus VP24 protein counteracts alpha/beta interferon (IFN-α/β) and IFN-γ signaling
by blocking the nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1) …

ABSTRACT The Ebola virus (EBOV) VP35 protein antagonizes the early antiviral alpha/beta
interferon (IFN-α/β) response. We previously demonstrated that VP35 inhibits the virus …

During antiviral defense, interferon (IFN) signaling triggers nuclear transport of tyrosine-
phosphorylated STAT1 (PY-STAT1), which occurs via a subset of karyopherin alpha (KPNA) …

The Zaire ebolavirus protein VP24 was previously demonstrated to inhibit alpha/beta
interferon (IFN-α/β)-and IFN-γ-induced nuclear accumulation of tyrosine-phosphorylated …

The structural protein VP24 of Ebola virus (EBOV) is a determinant of virulence in rodent
models and possesses an interferon antagonist function. In this study, we investigate the …

ABSTRACT The Ebola virus (EBOV) VP35 protein blocks the virus-induced phosphorylation
and activation of interferon regulatory factor 3 (IRF-3), a transcription factor critical for the …

The roles of Ebola virus (EBOV) VP24 in nucleocapsid (NC) formation and the effect of VP24
on transcription and replication of the viral genome during NC formation remain unknown …

The filoviruses, Ebola virus (EBOV) and Marburg virus (MARV), cause frequently lethal viral
hemorrhagic fever. These infections induce potent cytokine production, yet these host …

Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are
characterized by early suppression of the host innate immune system. One of the proteins …