Recent evidence clearly shows that cells respond to various physical cues in their
environments, guiding many cellular processes and tissue morphogenesis, pathology, and …

Surface curvature both emerges from, and influences the behavior of, living objects at length
scales ranging from cell membranes to single cells to tissues and organs. The relevance of …

In biological systems, form and function are inherently correlated. Despite this strong
interdependence, the biological effect of curvature has been largely overlooked or …

Signals from the microenvironment around a cell are known to influence cell behavior.
Material properties, such as biochemical composition and substrate stiffness, are today …

Individual cells and multicellular systems respond to cell-scale curvatures in their
environments, guiding migration, orientation, and tissue formation. However, it remains …

Adherent cells residing within tissues or biomaterials are presented with 3D geometrical
cues from their environment, often in the form of local surface curvatures. While there is …

The stiffness and nanotopographical characteristics of the extracellular matrix (ECM)
influence numerous developmental, physiological, and pathological processes in vivo …

In this report, we describe using ultraviolet (UV)-assisted capillary force lithography (CFL) to
create a model substratum of anisotropic micro-and nanotopographic pattern arrays with …

Cells come in a variety of shapes that most often underlie their functions. Regulation of cell
morphogenesis implies that there are mechanisms for shape sensing that still remain poorly …

The collective self-organization of cells into three-dimensional structures can give rise to
emergent physical properties such as fluid behavior. Here, we demonstrate that tissues …