ABC multidrug transporters: structure, function and role in chemoresistance
FJ Sharom - 2008 - Future Medicine
Three ATP-binding cassette (ABC)-superfamily multidrug efflux pumps are known to be
responsible for chemoresistance; P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2 …
responsible for chemoresistance; P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2 …
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade
Z Chen, T Shi, L Zhang, P Zhu, M Deng, C Huang, T Hu… - Cancer letters, 2016 - Elsevier
Multidrug resistance (MDR) is a serious phenomenon employed by cancer cells which
hampers the success of cancer pharmacotherapy. One of the common mechanisms of MDR …
hampers the success of cancer pharmacotherapy. One of the common mechanisms of MDR …
Pharmacogenomics of ABC transporters and its role in cancer chemotherapy
A Sparreboom, R Danesi, Y Ando, J Chan… - Drug Resistance …, 2003 - Elsevier
ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to
anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein), ABCC1 …
anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein), ABCC1 …
ABC transporters in multidrug resistance and pharmacokinetics, and strategies for drug development
Y Hee Choi, AM Yu - Current pharmaceutical design, 2014 - ingentaconnect.com
Multidrug resistance (MDR) is a serious problem that hampers the success of cancer
pharmacotherapy. A common mechanism is the overexpression of ATP-binding cassette …
pharmacotherapy. A common mechanism is the overexpression of ATP-binding cassette …
ABC efflux pump-based resistance to chemotherapy drugs
PDW Eckford, FJ Sharom - Chemical reviews, 2009 - ACS Publications
Over 1 million new cases of all types of cancer are diagnosed each year in the United States
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …
Revisiting the role of ABC transporters in multidrug-resistant cancer
Most patients who die of cancer have disseminated disease that has become resistant to
multiple therapeutic modalities. Ample evidence suggests that the expression of ATP …
multiple therapeutic modalities. Ample evidence suggests that the expression of ATP …
The role of ABC transporters in drug resistance, metabolism and toxicity
H Glavinas, P Krajcsi, J Cserepes… - Current drug …, 2004 - ingentaconnect.com
ATP Binding Cassette (ABC) transporters form a special family of membrane proteins,
characterized by homologous ATP-binding, and large, multispanning transmembrane …
characterized by homologous ATP-binding, and large, multispanning transmembrane …
[PDF][PDF] How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance
AC Jaramillo, F Al Saig, J Cloos, G Jansen… - Cancer Drug Resist, 2018 - f.oaes.cc
Abstract P-glycoprotein (ABCB1), multidrug resistance protein-1 (ABCC1) and breast cancer
resistance protein (ABCG2) belong to the ATP-binding cassette (ABC) superfamily of …
resistance protein (ABCG2) belong to the ATP-binding cassette (ABC) superfamily of …
The controversial role of ABC transporters in clinical oncology
The phenomenon of multidrug resistance in cancer is often associated with the
overexpression of the ABC (ATP-binding cassette) transporters Pgp (P …
overexpression of the ABC (ATP-binding cassette) transporters Pgp (P …
ABC transporters as mediators of drug resistance and contributors to cancer cell biology
JI Fletcher, RT Williams, MJ Henderson… - Drug Resistance …, 2016 - Elsevier
The extrusion of anticancer drugs by members of the ATP-binding cassette (ABC)
transporter family is one of the most widely recognized mechanisms of multidrug resistance …
transporter family is one of the most widely recognized mechanisms of multidrug resistance …