COVID-19 therapeutics: Challenges and directions for the future

PC Robinson, DFL Liew, HL Tanner… - Proceedings of the …, 2022 - National Acad Sciences
The emergence of SARS-CoV-2 triggering the COVID-19 pandemic ranks as arguably the
greatest medical emergency of the last century. COVID-19 has highlighted health disparities …

[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

[HTML][HTML] Treatments for COVID-19: Lessons from 2020 and new therapeutic options

F Salasc, T Lahlali, E Laurent, M Rosa-Calatrava… - Current Opinion in …, 2022 - Elsevier
To face the COVID-19 pandemic, prophylactic vaccines have been developed in record
time, but vaccine coverage is still limited, accessibility is not equitable worldwide, and the …

Tackling SARS-CoV-2: proposed targets and repurposed drugs

S Joshi, M Joshi, MS Degani - Future medicinal chemistry, 2020 - Future Science
The SARS-CoV-2 pandemic, declared as a global health emergency by the WHO in
February 2020, has currently infected more than 6 million people with fatalities near 371,000 …

[HTML][HTML] Repurposing drugs, ongoing vaccine, and new therapeutic development initiatives against COVID-19

RP Saha, AR Sharma, MK Singh, S Samanta… - Frontiers in …, 2020 - frontiersin.org
As the COVID-19 is still growing throughout the globe, a thorough investigation into the
specific immunopathology of SARS-CoV-2, its interaction with the host immune system and …

COVID-19: An overview of the current pharmacological interventions, vaccines, and clinical trials

R Chakraborty, S Parvez - Biochemical pharmacology, 2020 - Elsevier
COVID-19, the greatest public health emergency of the 21st century, has affected 215
countries and territories around the world resulting in 15,151,738 confirmed cases and …

Revisiting potential druggable targets against SARS‐CoV‐2 and repurposing therapeutics under preclinical study and clinical trials: A comprehensive review

AAM Sohag, MA Hannan, S Rahman… - Drug development …, 2020 - Wiley Online Library
Abstract Coronavirus disease‐19 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), is one of the most contagious diseases in human …

[PDF][PDF] Therapeutics and COVID-19: living guideline, 16 September 2022

World Health Organization - 2022 - apps.who.int
As of August 2022, there have been over 572 million confirmed cases of COVID-19 (9). The
pandemic has thus far claimed approximately 6.39 million lives (9). Vaccination is having a …

Trends in COVID-19 therapeutic clinical trials.

K Bugin, J Woodcock - Nature Reviews Drug Discovery, 2021 - go.gale.com
The COVID-19 pandemic has stimulated intense efforts to find effective therapeutics for all
stages of the disease. Unfortunately, the scope, scientific rigour and clinical value of …

Research and development on therapeutic agents and vaccines for COVID-19 and related human coronavirus diseases

C Liu, Q Zhou, Y Li, LV Garner, SP Watkins, LJ Carter… - 2020 - ACS Publications
Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2
virus, this disease has spread rapidly around the globe. Considering the potential threat of a …