Background IKZF1 deletions are associated with adverse outcomes in B-cell acute
lymphoblastic leukemia (B-ALL). We assessed the prevalence and clinical impact of …

Introduction: The most prevalent malignancy during childhood is B-cell acute lymphoblastic
leukemia (B-ALL). Many genetic variations are the causes of B-ALL. IKZF1 alterations are …

To assess the prognostic effect of different levels of IKZF1 gene deletions in pediatric B-cell
precursor acute lymphoblastic leukemia (BCP–ALL). IKZF1 Δ2–8/ALB deletions were …

IKZF1 deletion is a recurrent genomic alteration in B-cell acute lymphoblastic leukemia (B-
ALL) and is divided into dominant-negative (DN) and loss of function (LOF) deletions. The …

The IKZF1 gene encodes for Ikaros, a transcriptional factor in B-cell development. Deletions
in this gene have been associated with a worse prognosis in B-cell acute lymphoblastic …

BACKGROUND Deletions in IKZF1 are found in approximately 15% of children with B-cell
precursor acute lymphoblastic leukemia (BCP-ALL). There is strong evidence for the poor …

Deletions in IKZF1 are found in~ 15% of children with B-cell precursor acute lymphoblastic
leukemia (BCP-ALL). There is strong evidence for the poor prognosis of IKZF1 deletions …

Acute lymphoblastic leukemia (ALL) is a malignancy associated with altered lymphoid
precursor hyperplasia and accompanied with different genetic mutations. Few studies have …

Abstract IKZF1 (IKAROS family Zinc Finger 1) alteration is an essential regulator of both T-
and B-cell lineage specification with leukemogenic potential. IKZF1 deletion have been …

Background IKZF1deletion is an unfavorable factor in Philadelphia negative (Ph‐) B‐cell
acute lymphoblastic leukemia. However, the effects of IKZF1 deletions co‐existing genetic …