[HTML][HTML] Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles

E Touizer, A Alrubayyi, R Ford, N Hussain, PP Gerber… - Iscience, 2023 - cell.com
We assessed a cohort of people living with human immunodeficiency virus (PLWH)(n= 110)
and HIV negative controls (n= 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all …

[HTML][HTML] A third (booster) dose of the inactivated SARS-CoV-2 vaccine elicits immunogenicity and T follicular helper cell responses in people living with HIV

Z Lv, S Lv, Q Li, Y Xia, Z Feng, H Zhang… - Frontiers in …, 2023 - frontiersin.org
Introduction This study sought to explore the immunogenicity of a booster dose of an
inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in …

[HTML][HTML] Impact of SARS-CoV-2 vaccination on systemic immune responses in people living with HIV

C Bessen, C Plaza-Sirvent, A Simsek, J Bhat… - Frontiers in …, 2022 - frontiersin.org
Despite the development of vaccines, which protect healthy people from severe and life-
threatening Covid-19, the immunological responses of people with secondary …

Robust vaccine-induced as well as hybrid B-and T-cell immunity across SARS-CoV-2 vaccine platforms in people with HIV

ML Verburgh, L van Pul, M Grobben, A Boyd… - Microbiology …, 2023 - Am Soc Microbiol
Few studies have comprehensively compared severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) vaccine-induced and hybrid B-and T-cell responses in people …

[HTML][HTML] SARS-CoV-2 Vaccine-induced T-cell response after three doses in people living with HIV on antiretroviral therapy compared to seronegative controls (CTN …

Y Alexandrova, A Yero, RS Mboumba Bouassa… - Viruses, 2023 - mdpi.com
People living with HIV (PLWH) may be at risk for poor immunogenicity to certain vaccines,
including the ability to develop immunological memory. Here, we assessed T-cell …

Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition

T Nkosi, C Chasara, AO Papadopoulos, TL Nguni… - Elife, 2022 - elifesciences.org
In some instances, unsuppressed HIV has been associated with severe COVID-19 disease,
but the mechanisms underpinning this susceptibility are still unclear. Here, we assessed the …

[HTML][HTML] Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy

ZL Brumme, F Mwimanzi, HR Lapointe, PK Cheung… - npj Vaccines, 2022 - nature.com
Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain
incompletely characterized. We measured circulating antibodies against the SARS-CoV-2 …

SARS-CoV-2 viral clearance and evolution varies by type and severity of immunodeficiency

Y Li, MC Choudhary, J Regan, J Boucau… - Science translational …, 2024 - science.org
Despite vaccination and antiviral therapies, immunocompromised individuals are at risk for
prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but the …

[HTML][HTML] People with HIV receiving suppressive antiretroviral therapy show typical antibody durability after dual COVID-19 vaccination, and strong third dose …

HR Lapointe, F Mwimanzi, PK Cheung, Y Sang… - medRxiv, 2022 - ncbi.nlm.nih.gov
Background: Longer-term humoral responses to two-dose COVID-19 vaccines remain
incompletely characterized in people living with HIV (PLWH), as do initial responses to a …

[HTML][HTML] Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

A Alrubayyi, E Gea-Mallorquí, E Touizer… - Nature …, 2021 - nature.com
There is an urgent need to understand the nature of immune responses against SARS-CoV-
2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that …