Longitudinal imaging using PET/CT with collagen-I PET-tracer and MRI for assessment of fibrotic and inflammatory lesions in a rat lung injury model

I Mahmutovic Persson, N Fransén Pettersson… - Journal of clinical …, 2020 - mdpi.com
Non-invasive imaging biomarkers (IBs) are warranted to enable improved diagnostics and
follow-up monitoring of interstitial lung disease (ILD) including drug-induced ILD (DIILD). Of …

Utilizing MRI, [18F]FDG-PET and [89Zr]Zr-DFO-28H1 FAP-PET tracer to assess inflammation and fibrogenesis in a reproducible lung injury rat model: a multimodal …

M Boswinkel, R Raavé, A Veltien… - Frontiers in Nuclear …, 2023 - frontiersin.org
Objective Accurate imaging biomarkers that indicate disease progression at an early stage
are highly important to enable timely mitigation of symptoms in progressive lung disease. In …

Optimization of a collagen-targeted PET probe for molecular imaging of pulmonary fibrosis

P Désogère, LF Tapias, TA Rietz, N Rotile… - Journal of Nuclear …, 2017 - Soc Nuclear Med
There is a large unmet need for a simple, accurate, noninvasive, quantitative, and high-
resolution imaging modality to detect lung fibrosis at early stage and to monitor disease …

Type I collagen–targeted PET probe for pulmonary fibrosis detection and staging in preclinical models

P Désogère, LF Tapias, LP Hariri, NJ Rotile… - Science translational …, 2017 - science.org
Pulmonary fibrosis is scarring of the lungs that can arise from radiation injury, drug toxicity,
environmental or genetic causes, and for unknown reasons [idiopathic pulmonary fibrosis …

Cis-4-[18F] fluoro-L-proline PET imaging of pulmonary fibrosis in a rabbit model

WE Wallace, NC Gupta, AF Hubbs… - Journal of Nuclear …, 2002 - Soc Nuclear Med
A fluorinated analog of proline amino acid, cis-4-[18F] fluoro-l-proline (FP), was tested for
potential use in PET for detection and evaluation of pulmonary response to respirable …

PET/CT with 18F-FDG–and 18F-FBEM–labeled leukocytes for metabolic activity and leukocyte recruitment monitoring in a mouse model of pulmonary fibrosis

B Bondue, F Sherer, G Van Simaeys… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Idiopathic pulmonary fibrosis is characterized by a progressive and irreversible respiratory
failure. Validated noninvasive methods able to assess disease activity are essential for …

A multimodal imaging approach based on micro-CT and fluorescence molecular tomography for longitudinal assessment of bleomycin-induced lung fibrosis in mice

F Ruscitti, F Ravanetti, G Donofrio, Y Ridwan… - JoVE (Journal of …, 2018 - jove.com
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by the progressive
and irreversible destruction of lung architecture, which causes significant deterioration in …

Optimization of an Allysine-Targeted PET Probe for Quantifying Fibrogenesis in a Mouse Model of Pulmonary Fibrosis

S Shuvaev, RS Knipe, M Drummond, NJ Rotile… - Molecular Imaging and …, 2023 - Springer
Purpose Idiopathic pulmonary fibrosis (IPF) is a destructive lung disease with a poor
prognosis, an unpredictable clinical course, and inadequate therapies. There are currently …

[68 Ga]Ga-FAPI-46 PET for non-invasive detection of pulmonary fibrosis disease activity

ZT Rosenkrans, CF Massey, K Bernau… - European journal of …, 2022 - Springer
Purpose The lack of effective molecular biomarkers to monitor idiopathic pulmonary fibrosis
(IPF) activity or treatment response remains an unmet clinical need. Herein, we determined …

Imaging biomarkers and pathobiological profiling in a rat model of drug-induced interstitial lung disease induced by bleomycin

I Mahmutovic Persson, H Falk Håkansson… - Frontiers in …, 2020 - frontiersin.org
A large number of systemically administered drugs have the potential to cause drug-induced
interstitial lung disease (DIILD). We aim to characterize a model of DIILD in the rat and …