The pleiotropic hormone relaxin-2 plays a pivotal role in the physiology and pathology of the
cardiovascular system. Relaxin-2 exerts relevant regulatory functions in cardiovascular …

Despite the great effort of the medical community during the last decades, cardiovascular
diseases remain the leading cause of death worldwide, increasing their prevalence every …

Although originally characterised as a reproductive hormone, relaxin has emerged as a
multi-functional endocrine and paracrine factor that plays a number of important roles in …

The peptide hormone relaxin has traditionally been linked to the maternal adaptation of the
cardiovascular system during the first trimester of pregnancy. By promoting nitric oxide …

Relaxin is a hormone belonging to the so-called relaxin superfamily, which also includes
insulin-like peptides. Relaxin is best known for its effects on the female reproductive system …

The peptide hormone relaxin was originally linked to reproductive physiology, where it is
believed to mediate systemic and renal hemodynamic adjustments to pregnancy. Recently …

Highlights•Serelaxin (human relaxin-2) had raised hope as a possible cardiovascular
drug.•The clinical trials with serelaxin in acute heart failure gave disappointing …

The 7th International Conference in the series on 'Relaxin and related peptides' covered all
aspects of the basic biology of relaxin (human H2-relaxin), its potential clinical applications …

The insulin‐like peptide relaxin, originally identified as a hormone of pregnancy, is now
known to exert a range of pleiotropic effects including vasodilatory, anti‐fibrotic, angiogenic …

The availability of highly purified recombinant human relaxin, serelaxin, has allowed clinical
trials to be conducted in several indications and the elucidation of its pharmacology in …