Disruption of the integrity of the plasma membrane by amyloidogenic proteins is linked to the
pathogenesis of a number of common age-related diseases. Although accumulating …

Calcium dysregulation, membrane leakage and Aβ amyloid growth are hallmarks of
Alzheimer's disease. Here we show that Ca2+ ions inhibit membrane damage due to …

Alzheimer's Disease (AD) and Type 2 diabetes mellitus (T2DM) are two incurable diseases
both hallmarked by an abnormal deposition of the amyloidogenic peptides Aβ and Islet …

Protein conformational diseases, including Alzheimer's, Huntington's, and Parkinson's
diseases, result from protein misfolding, giving a distinct fibrillar feature termed amyloid …

The presence of fibrillar protein deposits (amyloid) of human islet amyloid polypeptide
(hIAPP) in the pancreatic islets of Langerhans is thought to be related to death of the insulin …

The toxicity of amyloid-forming peptides has been hypothesized to reside in the ability of
protein oligomers to interact with and disrupt the cell membrane. Much of the evidence for …

The aggregation of proteins is tightly controlled in living systems, and misfolded proteins are
normally removed before aggregation of the misfolded protein can occur. But for reasons not …

Human islet amyloid polypeptide (hIAPP), otherwise known as amylin, is a 37-residue
peptide hormone which is reported to be a common factor in protein misfolding disorders …

Increasing evidence suggests that amyloid peptides associated with a variety of
degenerative diseases induce neurotoxicity in their intermediate oligomeric state, rather …

Disruption of cell membranes by Aβ is believed to be one of the key components of Aβ
toxicity. However, the mechanism by which this occurs is not fully understood. Here, we …