Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Recent evidence suggests that the major pathways mediating cell cholesterol homeostasis
respond to a common signal: active membrane cholesterol. Active cholesterol is the fraction …

As the major sterol in mammals, cholesterol has many varied roles in fundamental cellular
processes. Besides acting as a precursor for hormones, bile acids, oxysterols and as a …

Cholesterol has evolved to fulfill sophisticated biophysical, cell signaling and endocrine
requirements of animal systems. At a cellular level, cholesterol is found in membranes …

Cholesterol is vital in mammals, but toxic in excess. Consequently, elaborate molecular
mechanisms have evolved to maintain this sterol within narrow limits. How cells sense …

Cholesterol plays an essential role in cell membrane synthesis and in cell growth and
differentiation. In mammalian cells, cholesterol can be synthesized from acetate precursors …

Cholesterol is an essential structural component in the cell membranes of most vertebrates.
The biophysical properties of cholesterol and the enzymology of cholesterol metabolism …

The synthesis of cholesterol requires more than 20 enzymes, many of which are intricately
regulated. Post-translational control of these enzymes provides a rapid means for modifying …

Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular
disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in …

Cholesterol plays a key role in many cellular processes, and is generated by cells through
de novo biosynthesis or acquired from exogenous sources through the uptake of low-density …