Functions of aquaporins in the eye

AS Verkman, J Ruiz-Ederra, MH Levin - Progress in retinal and eye …, 2008 - Elsevier
The aquaporins (AQPs) are integral membrane proteins whose main function is to transport
water across cell membranes in response to osmotic gradients. At the ocular surface, AQP1 …

Role of aquaporin water channels in eye function

AS Verkman - Experimental eye research, 2003 - Elsevier
The aquaporins (AQPs) are a family of more than 10 homologous water transporting
proteins expressed in many mammalian epithelia and endothelia. At least five AQPs are …

Aquaporins in the eye: expression, function, and roles in ocular disease

KL Schey, Z Wang, JL Wenke, Y Qi - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Background All thirteen known mammalian aquaporins have been detected in the eye.
Moreover, aquaporins have been identified as playing essential roles in ocular functions …

Aquaporins in complex tissues: distribution of aquaporins 1–5 in human and rat eye

S Hamann, T Zeuthen, ML Cour… - … of Physiology-Cell …, 1998 - journals.physiology.org
Multiple physiological fluid movements are involved in vision. Here we define the cellular
and subcellular sites of aquaporin (AQP) water transport proteins in human and rat eyes by …

Intact AQP0 performs cell-to-cell adhesion

SS Kumari, K Varadaraj - Biochemical and biophysical research …, 2009 - Elsevier
Aquaporins (AQPs) constitute a major conduit for movement of water across plasma
membranes. AQP0 is expressed in the fiber cells and is critical for lens transparency and …

Expression of aquaporins in the rat ocular tissue

RV Patil, I Saito, XUN Yang, MB Wax - Experimental eye research, 1997 - Elsevier
The aquaporins (AQPs) are a rapid growing family of water channel proteins found in
animals, plants and microorganisms that raise plasma membrane water permeability …

[HTML][HTML] Spatial expression of aquaporin 5 in mammalian cornea and lens, and regulation of its localization by phosphokinase A

SS Kumari, M Varadaraj, VS Yerramilli… - Molecular …, 2012 - ncbi.nlm.nih.gov
Purpose Aquaporins (AQPs) play a significant role in the movement of water across the
plasma membrane. In the eye, the cornea and lens are avascular with unique …

Functional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesion

SS Kumari, J Gandhi, MH Mustehsan, S Eren… - Experimental eye …, 2013 - Elsevier
Abstract Aquaporin 0 (AQP0) performs dual functions in the lens fiber cells, as a water pore
and as a cell-to-cell adhesion molecule. Mutations in AQP0 cause severe lens cataract in …

Verification and spatial localization of aquaporin-5 in the ocular lens

AC Grey, KL Walker, RS Petrova, J Han… - Experimental eye …, 2013 - Elsevier
Until recently, the lens was thought to express only two aquaporin (AQP) water channels,
AQP1 and AQP0. In this study we confirm lenticular AQP5 protein expression by Western …

Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production

D Zhang, L Vetrivel, AS Verkman - The Journal of general physiology, 2002 - rupress.org
Aquaporin (AQP) water channels are expressed in the eye at sites of aqueous fluid
production and outflow: AQP1 and AQP4 in nonpigmented ciliary epithelium, and AQP1 in …