Functions of aquaporins in the eye
AS Verkman, J Ruiz-Ederra, MH Levin - Progress in retinal and eye …, 2008 - Elsevier
The aquaporins (AQPs) are integral membrane proteins whose main function is to transport
water across cell membranes in response to osmotic gradients. At the ocular surface, AQP1 …
water across cell membranes in response to osmotic gradients. At the ocular surface, AQP1 …
Role of aquaporin water channels in eye function
AS Verkman - Experimental eye research, 2003 - Elsevier
The aquaporins (AQPs) are a family of more than 10 homologous water transporting
proteins expressed in many mammalian epithelia and endothelia. At least five AQPs are …
proteins expressed in many mammalian epithelia and endothelia. At least five AQPs are …
Aquaporins in the eye: expression, function, and roles in ocular disease
KL Schey, Z Wang, JL Wenke, Y Qi - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Background All thirteen known mammalian aquaporins have been detected in the eye.
Moreover, aquaporins have been identified as playing essential roles in ocular functions …
Moreover, aquaporins have been identified as playing essential roles in ocular functions …
Aquaporins in complex tissues: distribution of aquaporins 1–5 in human and rat eye
Multiple physiological fluid movements are involved in vision. Here we define the cellular
and subcellular sites of aquaporin (AQP) water transport proteins in human and rat eyes by …
and subcellular sites of aquaporin (AQP) water transport proteins in human and rat eyes by …
Intact AQP0 performs cell-to-cell adhesion
SS Kumari, K Varadaraj - Biochemical and biophysical research …, 2009 - Elsevier
Aquaporins (AQPs) constitute a major conduit for movement of water across plasma
membranes. AQP0 is expressed in the fiber cells and is critical for lens transparency and …
membranes. AQP0 is expressed in the fiber cells and is critical for lens transparency and …
Expression of aquaporins in the rat ocular tissue
RV Patil, I Saito, XUN Yang, MB Wax - Experimental eye research, 1997 - Elsevier
The aquaporins (AQPs) are a rapid growing family of water channel proteins found in
animals, plants and microorganisms that raise plasma membrane water permeability …
animals, plants and microorganisms that raise plasma membrane water permeability …
[HTML][HTML] Spatial expression of aquaporin 5 in mammalian cornea and lens, and regulation of its localization by phosphokinase A
SS Kumari, M Varadaraj, VS Yerramilli… - Molecular …, 2012 - ncbi.nlm.nih.gov
Purpose Aquaporins (AQPs) play a significant role in the movement of water across the
plasma membrane. In the eye, the cornea and lens are avascular with unique …
plasma membrane. In the eye, the cornea and lens are avascular with unique …
Functional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesion
SS Kumari, J Gandhi, MH Mustehsan, S Eren… - Experimental eye …, 2013 - Elsevier
Abstract Aquaporin 0 (AQP0) performs dual functions in the lens fiber cells, as a water pore
and as a cell-to-cell adhesion molecule. Mutations in AQP0 cause severe lens cataract in …
and as a cell-to-cell adhesion molecule. Mutations in AQP0 cause severe lens cataract in …
Verification and spatial localization of aquaporin-5 in the ocular lens
AC Grey, KL Walker, RS Petrova, J Han… - Experimental eye …, 2013 - Elsevier
Until recently, the lens was thought to express only two aquaporin (AQP) water channels,
AQP1 and AQP0. In this study we confirm lenticular AQP5 protein expression by Western …
AQP1 and AQP0. In this study we confirm lenticular AQP5 protein expression by Western …
Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production
D Zhang, L Vetrivel, AS Verkman - The Journal of general physiology, 2002 - rupress.org
Aquaporin (AQP) water channels are expressed in the eye at sites of aqueous fluid
production and outflow: AQP1 and AQP4 in nonpigmented ciliary epithelium, and AQP1 in …
production and outflow: AQP1 and AQP4 in nonpigmented ciliary epithelium, and AQP1 in …