Targeting cell death: pyroptosis, ferroptosis, apoptosis and necroptosis in osteoarthritis

J Yang, S Hu, Y Bian, J Yao, D Wang, X Liu… - Frontiers in cell and …, 2022 - frontiersin.org
New research has shown that the development of osteoarthritis (OA) is regulated by different
mechanisms of cell death and types of cytokines. Therefore, elucidating the mechanism of …

Current understanding of osteoarthritis pathogenesis and relevant new approaches

L Tong, H Yu, X Huang, J Shen, G Xiao, L Chen… - Bone research, 2022 - nature.com
Osteoarthritis (OA) is the most common degenerative joint disease that causes painful
swelling and permanent damage to the joints in the body. The molecular mechanisms of OA …

The role of apoptosis in the pathogenesis of osteoarthritis

SQ Xiao, M Cheng, L Wang, J Cao, L Fang… - International …, 2023 - Springer
Purpose Apoptosis is an important physiological process, making a great difference to
development and tissue homeostasis. Osteoarthritis (OA) is a chronic joint disease …

Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studies

S Cao, Y Wei, H Xu, J Weng, T Qi, F Yu, S Liu… - Frontiers in …, 2023 - frontiersin.org
Purpose Recent scientific reports have revealed a close association between ferroptosis
and the occurrence and development of osteoarthritis (OA). Nevertheless, the precise …

[HTML][HTML] Chondrocyte ferroptosis contribute to the progression of osteoarthritis

X Yao, K Sun, S Yu, J Luo, J Guo, J Lin, G Wang… - Journal of orthopaedic …, 2021 - Elsevier
Background Osteoarthritis (OA) is a complex process comprised of mechanical load,
inflammation, and metabolic factors. It is still unknown that if chondrocytes undergo …

[HTML][HTML] Pyroptosis plays a role in osteoarthritis

S An, H Hu, Y Li, Y Hu - Aging and disease, 2020 - ncbi.nlm.nih.gov
Recent studies have revealed novel forms of cell death beyond the canonical types of
cellular apoptosis and necrosis, and these novel forms of cell death are induced by extreme …

Insights on molecular mechanisms of chondrocytes death in osteoarthritis

E Charlier, B Relic, C Deroyer, O Malaise… - International journal of …, 2016 - mdpi.com
Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation.
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …

The role played by ferroptosis in osteoarthritis: evidence based on iron dyshomeostasis and lipid peroxidation

S Zhang, J Xu, H Si, Y Wu, S Zhou, B Shen - Antioxidants, 2022 - mdpi.com
Ferroptosis, a recently discovered regulated cell death modality, is characterised by iron-
dependent accumulation of lipid hydroperoxides, which can reach lethal levels but can be …

Ferroptosis Plays a Role in Human Chondrocyte of Osteoarthritis Induced by IL-1β In Vitro

W Xu, B Zhang, C Xi, Y Qin, X Lin, B Wang… - Cartilage, 2023 - journals.sagepub.com
Objective Osteoarthritis (OA) is a common disease with complex and unclear pathogenesis.
Ferroptosis is a new cell death mode, which is proved to be involved in different kinds of …

The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases

S Wang, H Wang, C Feng, C Li, Z Li, J He, C Tu - Cell Death Discovery, 2022 - nature.com
Pyroptosis is a controlled form of inflammatory cell death characterized by inflammasome
activation, pore formation, and cell lysis. According to different caspases, pyroptosis can be …