Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa).
The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress …

Radiotherapy is one of the curative mainstays of prostate cancer; however, its efficacy is
often diminished by tumor radioresistance. Depending on the stage of disease, tumors can …

Pancreatic ductal adenocarcinoma (PDAC) cells utilize a novel non-canonical pathway of
glutamine metabolism that is essential for tumor growth and redox balance. Inhibition of this …

Altered glutamine metabolism is a hallmark of cancer growth, forming the theoretical basis
for development of metabolic therapies as cancer treatments. Glutaminase (GLS), a crucial …

Radiation resistance is a critical problem in radiotherapy for cancer. Radiation kills tumor
cells mainly through causing DNA damage. Thus, efficiency of DNA damage repair is one of …

Glutamine is conditionally essential in cancer cells, being utilized as a carbon and nitrogen
source for macromolecule production, as well as for anaplerotic reactions fuelling the …

Cancer cells reprogram their metabolism towards aerobic glycolysis and elevated
glutaminolysis, which contributes to the aggressive phenotype. Understanding how these …

Glucose, chief metabolic support for cancer cell survival and growth, is mainly imported into
cells by facilitated glucose transporters (GLUTs). The increase in glucose uptake along with …

The new oncologic paradigm of precision medicine is focused on identifying metabolic,
proteomic, transcriptomic and genomic variabilities in tumors that can be exploited to tailor …

Pancreatic cancer is a lethal disease with poor prognosis. Gemcitabine has been the first
line systemic treatment for pancreatic cancer. However, the rapid development of drug …