Mutational analysis of patients with colorectal cancer in CALGB/SWOG 80405 identifies new roles of microsatellite instability and tumor mutational burden for patient …
F Innocenti, FS Ou, X Qu, TJ Zemla… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE CALGB/SWOG 80405 was a randomized phase III trial that found no statistically
significant difference in overall survival (OS) in patients with first-line metastatic colorectal …
significant difference in overall survival (OS) in patients with first-line metastatic colorectal …
[HTML][HTML] Multicenter retrospective analysis of metastatic colorectal cancer (CRC) with high-level microsatellite instability (MSI-H)
Background The microsatellite instability-high (MSI-H) phenotype, present in 15% of early
colorectal cancer (CRC), confers good prognosis. MSI-H metastatic CRC is rare and its …
colorectal cancer (CRC), confers good prognosis. MSI-H metastatic CRC is rare and its …
[HTML][HTML] Mutational profiling of colorectal cancers with microsatellite instability
Microsatellite instability (MSI) is caused by defective mismatch repair in 15–20% of
colorectal cancers (CRCs). Higher mutation loads in tumors with mismatch repair deficiency …
colorectal cancers (CRCs). Higher mutation loads in tumors with mismatch repair deficiency …
Pembrolizumab therapy for microsatellite instability high (MSI-H) colorectal cancer (CRC) and non-CRC.
LA Diaz, A Marabelle, JP Delord, R Shapira-Frommer… - 2017 - ascopubs.org
3071 Background: Mismatch repair deficient cancers harbor high levels of microsatellite
instability and somatic mutations. Treatment with anti-PD-1 antibodies has resulted in …
instability and somatic mutations. Treatment with anti-PD-1 antibodies has resulted in …
Efficacy and safety of atezolizumab (atezo) and bevacizumab (bev) in a phase Ib study of microsatellite instability (MSI)-high metastatic colorectal cancer (mCRC).
HS Hochster, JC Bendell, JM Cleary, P Foster… - 2017 - ascopubs.org
673 Background: Blockade of the PD-L1/PD-1 axis is a proven immunologic approach for
treatment of many cancers; however, not all pts respond to monotherapy. Bev, an anti–VEGF …
treatment of many cancers; however, not all pts respond to monotherapy. Bev, an anti–VEGF …
KEYNOTE-164: Pembrolizumab for patients with advanced microsatellite instability high (MSI-H) colorectal cancer.
3514 Background: Pembrolizumab is approved for the treatment of adult and pediatric
patients (pts) with previously treated MSI-H cancer regardless of tumor type or site. This …
patients (pts) with previously treated MSI-H cancer regardless of tumor type or site. This …
Microsatellite instability does not predict the efficacy of chemotherapy in metastatic colorectal cancer. A systematic review and meta-analysis
G Des Guetz, B Uzzan, P Nicolas… - Anticancer …, 2009 - ar.iiarjournals.org
Background: Microsatellite Instability (MSI) status is a good prognostic factor for colorectal
cancer (CRC) but its predictive value for chemosensitivity remains controversial. A previous …
cancer (CRC) but its predictive value for chemosensitivity remains controversial. A previous …
The impact of microsatellite stability status in colorectal cancer
Several forms of genomic instability are known to drive the development of colorectal cancer
(CRC). Chromosomal instability is the most common type found in 85% of the CRC, while …
(CRC). Chromosomal instability is the most common type found in 85% of the CRC, while …
Metastatic pattern of stage IV colorectal cancer with high-frequency microsatellite instability as a prognostic factor
K Fujiyoshi, G Yamamoto, T Takenoya… - Anticancer …, 2017 - ar.iiarjournals.org
Background: A recent clinical trial on the immune check-point inhibitor pembrolizumab
demonstrated that microsatellite instability (MSI) is a good biomarker for response to this …
demonstrated that microsatellite instability (MSI) is a good biomarker for response to this …
Clinicopathological characteristics of high microsatellite instability/mismatch repair-deficient colorectal cancer: a narrative review
WJ Mei, M Mi, J Qian, N Xiao, Y Yuan… - Frontiers in …, 2022 - frontiersin.org
Colorectal cancers (CRCs) with high microsatellite instability (MSI-H) and deficient mismatch
repair (dMMR) show molecular and clinicopathological characteristics that differ from those …
repair (dMMR) show molecular and clinicopathological characteristics that differ from those …
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