[HTML][HTML] Conceptualizing Lennox–Gastaut syndrome as a secondary network epilepsy

JS Archer, AEL Warren, GD Jackson… - Frontiers in neurology, 2014 - frontiersin.org
Lennox–Gastaut Syndrome (LGS) is a category of severe, disabling epilepsy, characterized
by frequent, treatment-resistant seizures, and cognitive impairment. Electroencephalography …

Abnormal cognitive network interactions in Lennox‐Gastaut syndrome: A potential mechanism of epileptic encephalopathy

AEL Warren, DF Abbott, DN Vaughan, GD Jackson… - …, 2016 - Wiley Online Library
Summary Objective In patients with Lennox‐Gastaut syndrome (LGS), recurrent epileptic
activity is thought to contribute to impaired cognition (epileptic encephalopathy). Using …

Lennox‐Gastaut syndrome and phenotype: secondary network epilepsies

JS Archer, AEL Warren, MR Stagnitti, RAJ Masterton… - …, 2014 - Wiley Online Library
Summary Objective Lennox‐Gastaut syndrome (LGS) is a severe epilepsy phenotype with
characteristic electroclinical features despite diverse etiologies. We previously found …

EEG‐fMRI reveals activation of brainstem and thalamus in patients with Lennox‐Gastaut syndrome

M Siniatchkin, D Coropceanu, F Moeller, R Boor… - …, 2011 - Wiley Online Library
Purpose: Even if etiologies of Lennox‐Gastaut syndrome (LGS) are diverse, the multiple
causes converge into a final common pathway that results in this specific epilepsy …

Lennox–Gastaut syndrome: a state of the art review

M Mastrangelo - Neuropediatrics, 2017 - thieme-connect.com
Lennox–Gastaut syndrome (LGS) is a severe age-dependent epileptic encephalopathy
usually with onset between 1 and 8 years of age. Functional neuroimaging studies recently …

The epileptic network of Lennox-Gastaut syndrome: cortically driven and reproducible across age

AEL Warren, AS Harvey, SJ Vogrin, C Bailey… - Neurology, 2019 - AAN Enterprises
Objective To identify brain regions underlying interictal generalized paroxysmal fast activity
(GPFA), and their causal interactions, in children and adults with Lennox-Gastaut syndrome …

Cortex leads the thalamic centromedian nucleus in generalized epileptic discharges in Lennox‐Gastaut syndrome

LJ Dalic, AEL Warren, JC Young, W Thevathasan… - …, 2020 - Wiley Online Library
Objective We aimed to assess the roles of the cortex and thalamus (centromedian nucleus
[CM]) during epileptic activity in Lennox‐Gastaut syndrome (LGS) patients undergoing deep …

Thalamocortical functional connectivity in Lennox–Gastaut syndrome is abnormally enhanced in executive‐control and default‐mode networks

AEL Warren, DF Abbott, GD Jackson, JS Archer - Epilepsia, 2017 - Wiley Online Library
Objective To identify abnormal thalamocortical circuits in the severe epilepsy of Lennox–
Gastaut syndrome (LGS) that may explain the shared electroclinical phenotype and provide …

Management of Lennox-Gastaut syndrome beyond childhood: A comprehensive review

D Samanta - Epilepsy & Behavior, 2021 - Elsevier
Lennox-Gastaut syndrome (LGS) is a childhood-onset epileptic encephalopathy
characterized by multiple types of medically intractable seizures, cognitive impairment, and …

Early diagnosis and treatment of Lennox-Gastaut syndrome

T Resnick, RD Sheth - Journal of Child Neurology, 2017 - journals.sagepub.com
Lennox-Gastaut syndrome (LGS) is a severe form of childhood-onset epilepsy associated
with high morbidity and mortality. The peak period for manifestations of Lennox-Gastaut …