In cystic fibrosis (CF) patients, hyper-inflammation is a key factor in lung destruction and
disease morbidity. We have previously demonstrated that macrophages drive the lung hyper …

Cystic fibrosis (CF) is the most common lethal genetic disease, caused by CFTR (cystic
fibrosis transmembrane conductance regulator) gene mutations. CF is characterized by an …

Cystic Fibrosis (CF) is characterized by a massive proinflammatory phenotype in the lung
arising from profound expression of inflammatory genes, including interleukin-8 (IL-8). We …

Persistent neutrophil-dominated lung inflammation contributes to lung damage in cystic
fibrosis (CF). However, the mechanisms that drive persistent lung neutrophilia and tissue …

Cystic fibrosis (CF) lung disease is characterized by chronic neutrophilic inflammation and
infection. Effective management of airway inflammation could complement other therapies …

Dysregulation of microRNAs (miRNAs) has been implicated in the pathogenesis of chronic
obstructive pulmonary disease (COPD), which is largely attributable to cigarette smoke (CS) …

Cystic fibrosis (CF) is due to mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) gene, which cause a massively proinflammatory phenotype in the CF …

In individuals with cystic fibrosis (CF), lung hyper-inflammation starts early in life and is
perpetuated by mucus obstruction and persistent bacterial infections. The continuous tissue …

Inflammatory lung disease is the major cause of morbidity and mortality in cystic fibrosis
(CF); understanding what produces dysregulated innate immune responses in CF cells will …

Cystic fibrosis (CF) is caused by a defect in the cystic fibrosis transmembrane conductance
regulator protein (CFTR) which instigates a myriad of respiratory complications including …