The ocular lens is a model system for understanding important aspects of embryonic
development, such as cell specification and the spatiotemporally controlled formation of a …

Ocular lens development represents an advantageous system in which to study regulatory
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …

Despite extensive study following the pioneering work of Spemann on lens development
(Spemann, H.(1901) Verh. Anat. Ges. 15, 61–79) and the subsequent establishment of the …

Since the pioneering work of the early 1900s, the lens has been used as a model system for
the study of tissue development in vertebrates. A number of embryological transplantation …

The lens was the first tissue in which the concept of embryonic induction was demonstrated.
For many years lens induction was thought to occur at the time the optic vesicle and lens …

This review gives a brief account of the main processes of lens development, including
induction, morphogenesis, differentiation and growth. It describes what is known about the …

The vertebrate eye lens has been used extensively as a model for developmental processes
such as determination, embryonic induction, cellular differentiation, transdifferentiation and …

During lens development in vertebrates, the orchestration of multiple transcriptional
regulators is essential for fate determination and terminal differentiation. In early …

The eye and lens represent excellent models to understand embryonic development at
cellular and molecular levels. Initial 3D formation of the eye depends on a reciprocal …

In this paper, the more recent literature pertaining to differentiation in the developing
vertebrate lens is reviewed in relation to previous work. The literature reviewed reveals that …