Synthesis, docking studies into CDK-2 and anticancer activity of new derivatives based pyrimidine scaffold and their derived glycosides
AAH Rahman, IF Nassar, AKF Shaban… - Mini Reviews in …, 2019 - ingentaconnect.com
Background & Objective: New diaryl-substituted pyrimidinedione compounds, their thioxo
derivatives as well as their bicyclic thiazole compounds were synthesized and …
derivatives as well as their bicyclic thiazole compounds were synthesized and …
Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine …
AA Mandour, IF Nassar, MT Abdel Aal… - Journal of enzyme …, 2022 - Taylor & Francis
Cyclin-dependent kinase inhibition is considered a promising target for cancer treatment for
its crucial role in cell cycle regulation. Pyrazolo pyrimidine derivatives were well established …
its crucial role in cell cycle regulation. Pyrazolo pyrimidine derivatives were well established …
Discovery of 3, 6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico …
A Sabt, WM Eldehna, T Al-Warhi… - Journal of Enzyme …, 2020 - Taylor & Francis
Human health in the current medical era is facing numerous challenges, especially cancer.
So, the therapeutic arsenal for cancer should be unremittingly enriched with novel small …
So, the therapeutic arsenal for cancer should be unremittingly enriched with novel small …
Design and synthesis of pyrimidine molecules endowed with thiazolidin-4-one as new anticancer agents
Abstract Design and synthesis of new pyrimidine derivatives clubbed with thiazolidin-4-one
from 4-(2-chlorophenyl)-6-(2, 4-dichlorophenyl) pyrimidin-2-amine and their in vitro …
from 4-(2-chlorophenyl)-6-(2, 4-dichlorophenyl) pyrimidin-2-amine and their in vitro …
Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with …
In the current study, virtual screening of a small library of 1302 pyrrolizines bearing
urea/thiourea moieties was performed. The top-scoring hits were synthesised and evaluated …
urea/thiourea moieties was performed. The top-scoring hits were synthesised and evaluated …
Design, synthesis and anticancer activity of new thiazole-tetrazole or triazole hybrid glycosides targeting CDK-2 via structure-based virtual screening
AF Kassem, EMH Abbas, DS El-Kady… - Mini Reviews in …, 2019 - ingentaconnect.com
Background & Objective: The target tetrazole glycosides were synthesized by construction of
ring system by cycloaddition reaction of benzothiazole-linked nitrile derivative and sodium …
ring system by cycloaddition reaction of benzothiazole-linked nitrile derivative and sodium …
Synthesis, anticancer evaluation, CDK2 inhibition, and apoptotic activity assessment with molecular docking modeling of new class of pyrazolo[1,5-a]pyrimidines
NH Metwally, MS Mohamed, EA Deeb - Research on Chemical …, 2021 - Springer
Cyanopyrazolo [1, 5-a] pyrimidine derivative 3 reacted with some aromatic aldehydes,
arenediazonium salts, hydrazine hydrate, and guanidine hydrochloride to create a series of …
arenediazonium salts, hydrazine hydrate, and guanidine hydrochloride to create a series of …
Design, synthesis and biological evaluation of certain CDK2 inhibitors based on pyrazole and pyrazolo [1, 5-a] pyrimidine scaffold with apoptotic activity
GME Ali, DA Ibrahim, AM Elmetwali, NSM Ismail - Bioorganic Chemistry, 2019 - Elsevier
Different series of novel pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives (2a-g),(3a-
c),(7a-d) and (10a-e) were designed, synthesized and evaluated for their ability to inhibit …
c),(7a-d) and (10a-e) were designed, synthesized and evaluated for their ability to inhibit …
Design, synthesis, anticancer evaluation and molecular docking study of novel 2, 4-dichlorophenoxymethyl-based derivatives linked to nitrogenous heterocyclic ring …
Abstract A novel series of 2, 4-dichlorophenoxymethyl-based derivatives 4-18 bearing
various nitrogenous heterocyclic systems have been designed and synthesized through …
various nitrogenous heterocyclic systems have been designed and synthesized through …
Synthesis of 4, 6-disubstituted pyrazolo [3, 4-d] pyrimidine analogues: Cyclin-dependent kinase 2 (CDK2) inhibition, molecular docking and anticancer evaluation
S Cherukupalli, B Chandrasekaran, RR Aleti… - Journal of Molecular …, 2019 - Elsevier
The cyclin-dependent kinases (CDKs) play a crucial role in cell cycle progression and are
validated targets of cancer therapy. Pyrazolopyrimidines are versatile scaffolds, which have …
validated targets of cancer therapy. Pyrazolopyrimidines are versatile scaffolds, which have …
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