Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of
cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead …

Seventeen new amide/sulfonamide containing nimesulide derivatives were synthesized and
characterized by several spectroscopic techniques and primarily investigated for their …

Nimesulide is a nonsteroidal anti-inflammatory drug possessing analgesic and antipyretic
properties. This drug is considered a selective cyclooxygenase-2 (COX-2) inhibitor and …

Cyclooxygenase (COX) inhibitors Indomethacin and its structural analogs Sulindac exhibit
cell growth inhibition and apoptosis inducing activities in various cancer cell lines via COX …

Non-steroidal anti-inflammatory drugs (NSAIDs), which are known to be cyclooxygenase
(COX) inhibitors, have been reported to exert anti-proliferative and pro-apoptotic effects on a …

JCC76 is a derivative of cyclooxygenase-2 (COX-2) selective inhibitor nimesulide and
exhibits potent anti-breast cancer activity. It selectively induces apoptosis of Her2 positive …

Over the last few decades, a growing body of studies addressed the anticancer activity of
NSAIDs, particularly selective COX-2 inhibitors. However, their exact molecular mechanism …

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) developed as a selective
inhibitor of cyclooxygenase-2 (COX-2) for the treatment of rheumatoid arthritis disease …

In this paper, the binding mode of original pyridinic compounds structurally related to
nimesulide, a preferential cyclooxygenase (COX)-2 inhibitor, is analyzed by docking …

A series of COX-2 selective inhibitor nimesulide derivatives were synthesized. Their anti-cell
proliferation activities were evaluated with a long-term estrogen deprived MCF-7aro …