1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …

P-glycoprotein is the product of the ABCB1 [also known as multidrug resistance 1 (MDR1)]
gene. It translocates a broad variety of xenobiotics out of cells. P-glycoprotein was first …

Resistance to chemically different natural product anti-cancer drugs (multidrug resistance, or
MDR) results from decreased drug accumulation, resulting from expression of one or more …

P-glycoprotein is an ATP-dependent efflux pump that contributes to the protection of the
body from environmental toxins. It transports a huge variety of structurally diverse …

1. P-glycoprotein (P-gp) is a transmembrane protein involved in ATP-dependent efflux of
various structurally unrelated anticancer drugs. Its overexpression in cancer cells decreases …

P-glycoprotein (Pgp), which is coded by human MDR1 (multidrug resistance) gene, is an
energy-dependent efflux pump that exports its substrates out of the cell. Human Pgp is …

Multidrug resistance (MDR) of cancer tissue is a phenomenon in which cancer cells exhibit
reduced sensitivity to a large group of unrelated drugs with different mechanisms of …

In humans, there are two P-glycoprotein (P-gp) transporters encoded by MDR1 (PGY1) and
MDR3 (also named MDR2 and PGY3) adjacently located at the chromosomal region 7q21 …

ATP-binding cassette (ABC) drug efflux transporters limit intracellular concentration of their
substrates by pumping them out of cell through an active, energy dependent mechanism …

The MDR1 (ABCB1) gene product P-glycoprotein is a membrane protein, which functions as
an ATP-dependent exporter of xenobiotics from cells. Its importance was first recognized …