Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-
1β (IL-1β) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes …

Cryopyrin, or NALP3, is the central component of the cryopyrin inflammasome. Cryopyrin
contains three domains: a pyrin domain (PYD), a nucleoside oligomerization domain (NOD) …

The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of
human diseases. A few compounds have been developed to inhibit NLRP3 inflammasome …

The innate immune system is critical in recognizing bacterial and viral infections to evoke a
proper immune response. Certain members of the intracellular nucleotide‐binding and …

The NLRP3 inflammasome is a critical component of the innate immune system that
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …

In a recent publication in Nature, Ising et al. reported the effect of the NLRP3 inflammasome
on Aβ-induced tau pathology in Alzheimer's disease (AD). The findings indicate that NLRP3 …

NLRP3 inflammasome plays a key role in the intracellular activation of caspase‐1,
processing of pro‐inflammatory interleukin‐1β (IL‐1β), and pyroptotic cell death cascade …

The dysregulation of NLRP 3 inflammasome can cause uncontrolled inflammation and drive
the development of a wide variety of human diseases, but the medications targeting NLRP 3 …

Cryopyrin is essential for caspase-1 activation triggered by Toll-like receptor (TLR) ligands
in the presence of adenosine triphosphate (ATP). However, the events linking bacterial …

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory
form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The …