Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites.
Renal drug transporters, which are primarily located in the renal proximal tubules, play an …

Carrier-mediated processes, often referred to as transporters, play key roles in the
reabsorption and secretion of many endogenous and xenobiotic compounds by the kidney …

One of most important functions of the kidney concerns the clearance of endogenous waste
products, exogenously administered drugs as well as environmental exposures. In addition …

Drug transporters play an essential role in disposition and effects of multiple drugs. Plasma
concentrations of the victim drug can be modified by drug–drug interactions occurring in …

By utilizing filtration, active secretion and reabsorption processes, the kidney can conserve
essential nutrients, and eliminate drugs and potentially toxic compounds. Active uptake of …

In the kidney, human organic cation transporters (OCTs) and multidrug and toxin extrusion
proteins (MATEs) are the major transporters for the secretion of cationic drugs into the urine …

The kidney plays a vital role in the body's defense against potentially toxic xenobiotics and
metabolic waste products through elimination pathways. In particular, secretory transporters …

▪ Abstract Multiple organic anion transporters in the proximal tubule of the kidney are
involved in the secretion of drugs, toxic compounds, and their metabolites. Many of these …

renal elimination of a number of cationic compounds is thought to be mediated by the
organic cation transporter 2 (OCT2, SLC22A2), a drug uptake transporter expressed at the …