Effect of prophylactic levosimendan on all-cause mortality in pediatric patients undergoing cardiac surgery—an updated systematic review and meta-analysis
H Wang, Q Luo, Y Li, L Zhang, X Wu, F Yan - Frontiers in Pediatrics, 2020 - frontiersin.org
Background: Levosimendan, a calcium sensitizer, enhances the myocardial function by
generating more energy-efficient myocardial contractility than that achieved through …
generating more energy-efficient myocardial contractility than that achieved through …
Effect of levosimendan treatment in pediatric patients with cardiac dysfunction: an update of a systematic review and meta-analysis of randomized controlled trials
S Silvetti, A Belletti, S Bianzina, M Momeni - Journal of cardiothoracic and …, 2022 - Elsevier
Levosimendan increasingly has been used to treat heart failure and cardiac dysfunction in
pediatric patients. Currently, there is only limited evidence that this drug positively affects …
pediatric patients. Currently, there is only limited evidence that this drug positively affects …
Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease
J Hummel, G Ruecker, B Stiller - Cochrane Database of …, 2017 - cochranelibrary.com
Background Low cardiac output syndrome remains a serious complication, and accounts for
substantial morbidity and mortality in the postoperative course of paediatric patients …
substantial morbidity and mortality in the postoperative course of paediatric patients …
Levosimendan in paediatric cardiac anaesthesiology: A systematic review and meta-analysis
BACKGROUND Low cardiac output syndrome (LCOS) after congenital cardiac surgery has
an incidence of up to 25%. Preventing and treating LCOS is of pivotal importance as LCOS …
an incidence of up to 25%. Preventing and treating LCOS is of pivotal importance as LCOS …
Meta-analysis of trials on prophylactic use of levosimendan in patients undergoing cardiac surgery
Background The role of prophylactic levosimendan in patients undergoing cardiac surgery is
controversial. Methods We performed a computerized search of Medline, Embase, and …
controversial. Methods We performed a computerized search of Medline, Embase, and …
Levosimendan reduces mortality and low cardiac output syndrome in cardiac surgery
C Weber, M Esser, K Eghbalzadeh… - The Thoracic and …, 2020 - thieme-connect.com
Background There has been conflicting evidence concerning the effect of levosimendan on
clinical outcomes in patients undergoing cardiac surgery. Therefore, we performed a …
clinical outcomes in patients undergoing cardiac surgery. Therefore, we performed a …
Prophylactic use of levosimendan in preoperative setting for surgical repair of congenital heart disease in children
L Wannaz, L Boillat, MH Perez, S Di Bernardo - Frontiers in Pediatrics, 2023 - frontiersin.org
Introduction Low cardiac output syndrome (LCOS) is a significant cause of morbidity and the
leading cause of mortality after pediatric cardiac surgery. Levosimendan has been shown …
leading cause of mortality after pediatric cardiac surgery. Levosimendan has been shown …
Prophylactic use of levosimendan in pediatric patients undergoing cardiac surgery: a prospective randomized controlled trial
A Wang, C Cui, Y Fan, J Zi, J Zhang, G Wang, F Wang… - Critical Care, 2019 - Springer
Background The administration of levosimendan prophylactically to patients undergoing
cardiac surgery remains a controversial practice, and few studies have specifically assessed …
cardiac surgery remains a controversial practice, and few studies have specifically assessed …
Levosimendan versus milrinone in neonates and infants after corrective open-heart surgery: a pilot study
E Lechner, A Hofer, G Leitner-Peneder… - Pediatric Critical Care …, 2012 - journals.lww.com
Objective: Low cardiac output syndrome commonly complicates the postoperative course
after open-heart surgery in children. To prevent low cardiac output syndrome, prophylactic …
after open-heart surgery in children. To prevent low cardiac output syndrome, prophylactic …
Levosimendan for perioperative cardioprotection: myth or reality?
E Santillo, M Migale, C Massini… - Current Cardiology …, 2018 - ingentaconnect.com
Background: Levosimendan is a calcium sensitizer drug causing increased contractility in
the myocardium and vasodilation in the vascular system. It is mainly used for the therapy of …
the myocardium and vasodilation in the vascular system. It is mainly used for the therapy of …
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