In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a
molecule already recognized as an important regulator of cell survival, inflammation and …

Necroptosis, a form of regulated necrotic cell death mediated by RIPK1 (receptor-interacting
protein kinase 1) kinase activity, RIPK3, and MLKL (mixed-lineage kinase domain-like …

Receptor interacting protein kinase 3 (RIPK3) is an essential serine/threonine kinase for
necroptosis, a type of regulated necrosis. A variety of stimuli can cause RIPK3 activation …

Necroptosis is a regulated form of necrosis, with the dying cell rupturing and releasing
intracellular components that can trigger an innate immune response. Toll-like receptor 3 …

Necroptosis is a form of regulated cell death, which is induced by ligand binding to TNF
family death domain receptors, pattern recognizing receptors and virus sensors. The …

A process of regulated necrosis, termed necroptosis, has been recognized as a major
contributor to cell death and inflammation occurring under a wide range of pathologic …

Necroptosis is a lytic, inflammatory cell death pathway that is dysregulated in many human
pathologies. The pathway is executed by a core machinery comprising the RIPK1 and …

Necroptosis is a caspase-independent, lytic form of programmed cell death whose errant
activation has been widely implicated in many pathologies. The pathway relies on the …

Programmed cell death has a vital role in embryonic development and tissue homeostasis.
Necroptosis is an alternative mode of regulated cell death mimicking features of apoptosis …

RIPK1 and RIPK3 (receptor-interacting serine/threonine protein kinases 1/3) interact by
virtue of their RIP homotypic interaction motifs to mediate a form of cell death called …