The neuroinflammatory hypothesis of delirium

J Cerejeira, H Firmino, A Vaz-Serra… - Acta …, 2010 - Springer
Delirium is a neuropsychiatric syndrome characterized by a sudden and global impairment
in consciousness, attention and cognition. It is particularly frequent in elderly subjects with …

The immunology of delirium

J Cerejeira, L Lagarto… - …, 2014 - karger.com
Delirium is an acute neuropsychiatric syndrome characterized by acute-onset global
cognitive deficits, perceptual and behavioural disturbances affecting mainly elderly subjects …

Pathophysiology of delirium

RC van der Mast - Journal of geriatric psychiatry and …, 1998 - journals.sagepub.com
Hypotheses about the pathophysiology of delirium are speculative and largely based on
animal research. According to the neurotransmitter hypothesis, decreased oxidative …

The role of inflammation in the pathogenesis of delirium and dementia in older adults: a review

MJ Simone, ZS Tan - CNS neuroscience & therapeutics, 2011 - Wiley Online Library
Aims: To review recent evidence that suggests inflammation plays a similar role in the
pathogenesis of delirium and dementia. Methods: We performed a literature search of …

Neural mechanisms of delirium: current hypotheses and evolving concepts

JM Flacker, LA Lipsitz - Journals of Gerontology Series A …, 1999 - academic.oup.com
The purpose of this article is to review current knowledge regarding potential neural
mechanisms of delirium. A MEDLINE search for relevant English language articles was …

Systemic inflammation and delirium: important co-factors in the progression of dementia

C Cunningham - Biochemical Society Transactions, 2011 - portlandpress.com
It is widely accepted that inflammation plays some role in the progression of chronic
neurodegenerative diseases such as AD (Alzheimer's disease), but its precise role remains …

Introduction: Elucidating the pathophysiology of delirium and the interrelationship of delirium and dementia

SK Inouye, L Ferrucci - The Journals of Gerontology Series A …, 2006 - academic.oup.com
DELIRIUM, defined as an acute decline of attention and cognitive function, represents a
common and potentially devastating problem for hospitalized older persons. With …

[HTML][HTML] Delirium in elderly people: a review

S Martins, L Fernandes - Frontiers in neurology, 2012 - frontiersin.org
The present review aims to highlight this intricate syndrome, regarding diagnosis,
pathophysiology, etiology, prevention, and management in elderly people. The diagnosis of …

Neuroinflammation in delirium: a postmortem case-control study

BC van Munster, E Aronica, AH Zwinderman… - Rejuvenation …, 2011 - liebertpub.com
Background: Delirium can be hypothesized to be an extreme manifestation of sickness
behavior in elderly persons with neurodegenerative disease. The purpose of this study was …

Neuropathogenesis of delirium: review of current etiologic theories and common pathways

JR Maldonado - The American Journal of Geriatric Psychiatry, 2013 - Elsevier
Delirium is a neurobehavioral syndrome caused by dysregulation of neuronal activity
secondary to systemic disturbances. Over time, a number of theories have been proposed in …