OBJECTIVE: The composition of articular cartilage changes with progression of
osteoarthritis. Since compositional changes are associated with changes in the mechanical …

Osteoarthritis is a harmful joint disease but prediction of disease progression is problematic.
Currently, there is only one modeling framework which can be applied to predict the …

OBJECTIVE: Osteoarthritis (OA) is characterized by the changes in structure and
composition of articular cartilage. However, it is not fully known, what is the depth-wise …

For this study, we hypothesized that the depth-dependent compressive equilibrium
properties of articular cartilage are the inherent consequence of its depth-dependent …

From a mechanical point of view, the most relevant components of articular cartilage are the
tight and highly organized collagen network together with the charged proteoglycans. Due to …

The depth dependence of the material properties is present in normal adult cartilage and is
believed to have significant implications in its normal mechanical function. Cartilage …

The understanding of load support mechanisms in cartilage has evolved with computational
models that better mimic the tissue ultrastructure. Fibril-reinforced poroelastic models can …

The function of articular cartilage depends on its structure and composition, sensitively
impaired in disease (eg osteoarthritis, OA). Responses of chondrocytes to tissue loading are …

Cartilage defects are a known risk factor for osteoarthritis. Estimation of structural changes in
these defects could help us to identify high risk defects and thus to identify patients that are …

There is a long history of mathematical and computational modelling with the objective of
understanding the mechanisms governing cartilage׳ s remarkable mechanical performance …