The efficient total synthesis of the recently described natural substance largazole (1) and its
active metabolite largazole thiol (2) is described. The synthesis required eight linear steps …

Full details of the concise and convergent synthesis (eight steps, 19% overall yield), its
extension to the preparation of a series of key analogues, and the molecular target and …

Largazole 4a and analogues with modifications at the C7 position, as well as 2, 4′-
bithiazole 5a, have been synthesized using an acyclic cross-metathesis of the …

The histone deacetylase inhibitor largazole 1 was synthesized by a convergent approach
that involved several efficient and high yielding single pot multistep protocols. Initial attempts …

Details of the evolution of strategies toward convergent assembly of the histone deacetylase
inhibiting natural product largazole exploiting γ, δ-unsaturated-α, β-epoxy-aldehydes and a …

To characterize largazole's structural requirements for histone deacetylase (HDAC)
inhibitory and antiproliferative activities, a series of analogues with modifications to the side …

Largazole is a macrocyclic depsipeptide originally isolated from the marine cyanobacterium
Symploca sp., which is indigenous to the warm, blue-green waters of Key Largo, Florida …

Largazole is a potent and class I-selective histone deacetylase (HDAC) inhibitor purified
from marine cyanobacteria and was demonstrated to possess antitumor activity. Largazole …

An enantioselective total synthesis of the cytotoxic natural product (+)-largazole (1) is
described. It is a potent histone deacetylase inhibitor. Our synthesis is convergent and …

Histone deacetylases (HDACs) are validated targets for anticancer therapy as attested by
the approval of suberoylanilide hydroxamic acid (SAHA) and romidepsin (FK228) for treating …