Biomaterial surface hydrophobicity-mediated serum protein adsorption and immune responses

RM Visalakshan, MN MacGregor… - … applied materials & …, 2019 - ACS Publications
The nature of the protein corona forming on biomaterial surfaces can affect the performance
of implanted devices. This study investigated the role of surface chemistry and wettability on …

Tuning foreign body response with tailor-engineered nanoscale surface modifications: fundamentals to clinical applications

TC Yadav, A Bachhuka - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Biomaterials are omnipresent in today's healthcare services and are employed in various
applications, including implants, sensors, healthcare accessories, and drug delivery …

Surface chemistry influences implant biocompatibility

L Tang, P Thevenot, W Hu - Current topics in medicinal …, 2008 - ingentaconnect.com
Implantable medical devices are increasingly important in the practice of modern medicine.
Unfortunately, almost all medical devices suffer to a different extent from adverse reactions …

Impact of protein pre-coating on the protein corona composition and nanoparticle cellular uptake

V Mirshafiee, R Kim, S Park, M Mahmoudi, ML Kraft - Biomaterials, 2016 - Elsevier
Nanoparticles (NPs) are functionalized with targeting ligands to enable selectively delivering
drugs to desired locations in the body. When these functionalized NPs enter the blood …

Systematic approach to characterize the dynamics of protein adsorption on the surface of biomaterials using proteomics

J Kim - Colloids and Surfaces B: Biointerfaces, 2020 - Elsevier
Protein adsorption on biomaterial surfaces has been investigated in the development of
protein-repellent implantable devices. While the study of the adsorption of a single protein …

Innate immunity activation on biomaterial surfaces: a mechanistic model and coping strategies

KN Ekdahl, JD Lambris, H Elwing, D Ricklin… - Advanced drug delivery …, 2011 - Elsevier
When an artificial biomaterial (eg, a stent or implantable pump) is exposed to blood, plasma
proteins immediately adhere to the surface, creating a new interface between the …

Conformational and organizational insights into serum proteins during competitive adsorption on self-assembled monolayers

A Hasan, G Waibhaw, LM Pandey - Langmuir, 2018 - ACS Publications
Physicochemical interactions of proteins with surfaces mediate the interactions between the
implant and the biological system. Surface chemistry of the implant is crucial as it regulates …

Controlling protein adsorption through nanostructured polymeric surfaces

I Firkowska‐Boden, X Zhang… - Advanced healthcare …, 2018 - Wiley Online Library
The initial host response to healthcare materials' surfaces after implantation is the
adsorption of proteins from blood and interstitial fluids. This adsorbed protein layer …

Surface-induced changes in protein adsorption and implications for cellular phenotypic responses to surface interaction

LT Allen, M Tosetto, IS Miller, DP O'Connor… - Biomaterials, 2006 - Elsevier
Understanding external factors that determine cellular phenotypic responses is of key
interest in the field of biomaterials. Currently, material surface characteristics, protein …

Biomaterials: protein-surface interactions

RA Latour - Encyclopedia of biomaterials and biomedical …, 2005 - taylorfrancis.com
The study of protein–surface interactions represents one of the most important topics in the
field of biomaterials, and as such, it has been a focus of intensive study for several decades …