[HTML][HTML] Recent advances in aptamer discovery and applications

Y Zhang, BS Lai, M Juhas - Molecules, 2019 - mdpi.com
Aptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be
developed with high affinity and specificity to interact with any desired targets. They have …

Aptamers: molecules of great potential

F Radom, PM Jurek, MP Mazurek, J Otlewski… - Biotechnology …, 2013 - Elsevier
Aptamers emerged over 20 years ago as a class of nucleic acids able to recognize specific
targets. Today, aptamer-related studies constitute a large and important field of …

[HTML][HTML] Application of aptamers in diagnostics, drug-delivery and imaging

C Chandola, S Kalme, MG Casteleijn, A Urtti… - Journal of …, 2016 - Springer
Aptamers are small, single-stranded oligonucleotides (DNA or RNA) that bind to their target
with high specificity and affinity. Although aptamers are analogous to antibodies for a wide …

Aptamers: multifunctional molecules for biomedical research

J Banerjee, M Nilsen-Hamilton - Journal of molecular medicine, 2013 - Springer
Aptamers are single-stranded oligonucleotides that fold into well-defined three-dimensional
shapes, allowing them to bind their targets with high affinity and specificity. They can be …

[HTML][HTML] Three decades of nucleic acid aptamer technologies: Lessons learned, progress and opportunities on aptamer development

T Wang, C Chen, LM Larcher, RA Barrero… - Biotechnology …, 2019 - Elsevier
Aptamers are short single-stranded nucleic acid sequences capable of binding to target
molecules in a way similar to antibodies. Due to various advantages such as prolonged …

Aptamers: current challenges and future prospects

GT Rozenblum, VG Lopez, AD Vitullo… - Expert opinion on drug …, 2016 - Taylor & Francis
Introduction: Aptamers are oligonucleotide molecules raised in vitro from large combinatorial
libraries of nucleic acids and developed to bind to targets with high affinity and specificity …

[HTML][HTML] Current perspectives on aptamers as diagnostic tools and therapeutic agents

P Kumar Kulabhusan, B Hussain, M Yüce - Pharmaceutics, 2020 - mdpi.com
Aptamers are synthetic single-stranded DNA or RNA sequences selected from combinatorial
oligonucleotide libraries through the well-known in vitro selection and iteration process …

Challenges and opportunities for small molecule aptamer development

M McKeague, MC DeRosa - Journal of nucleic acids, 2012 - Wiley Online Library
Aptamers are single‐stranded oligonucleotides that bind to targets with high affinity and
selectivity. Their use as molecular recognition elements has emerged as a viable approach …

[HTML][HTML] Nucleic acid aptamers for target validation and therapeutic applications

PS Pendergrast, HN Marsh, D Grate… - Journal of …, 2005 - ncbi.nlm.nih.gov
In the simplest view, aptamers can be thought of as nucleic acid analogs to antibodies. They
are able to bind specifically to proteins, and, in many cases, that binding leads to a …

Recent progress in aptamer discoveries and modifications for therapeutic applications

S Ni, Z Zhuo, Y Pan, Y Yu, F Li, J Liu… - … Applied Materials & …, 2020 - ACS Publications
Aptamers are oligonucleotide sequences with a length of about 25–80 bases which have
abilities to bind to specific target molecules that rival those of monoclonal antibodies. They …