Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …

There have been considerable recent advances towards a better understanding of the
complex cellular and molecular network underlying liver fibrogenesis. Recent data indicate …

Liver fibrosis is the common scarring reaction associated with chronic liver injury that results
from prolonged parenchymal cell injury and/or inflammation. The fibrogenic response is …

Hepatic fibrosis is the common end point to chronic injury of varied aetiology. There is now
excellent evidence in both human studies and animal models that liver fibrosis is a …

Hepatic fibrosis is a wound‐healing response to chronic liver injury, which if persistent leads
to cirrhosis and liver failure. Exciting progress has been made in understanding the …

Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks
that regulate the deposition of extracellular matrix. This cascade of responses drives the …

Liver fibrosis is the generic response to chronic injury of varying aetiologies. A number of
common mechanisms link this response to the pathogenesis of fibrosis in other organs …

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …

With evidence from a large number of animal models and clinical trials, it is now beyond
debate that liver fibrosis and even cirrhosis are potentially reversible if the underlying cause …

Detailed analysis of the cellular and molecular mechanisms that mediate liver fibrosis has
provided a framework for therapeutic approaches to prevent, slow down, or even reverse …