Awakening: Predicting external stimulation to force transitions between different brain states

G Deco, J Cruzat, J Cabral… - Proceedings of the …, 2019 - National Acad Sciences
A fundamental problem in systems neuroscience is how to force a transition from one brain
state to another by external driven stimulation in, for example, wakefulness, sleep, coma, or …

[HTML][HTML] Perturbations in dynamical models of whole-brain activity dissociate between the level and stability of consciousness

Y Sanz Perl, C Pallavicini, I Pérez Ipiña… - PLoS computational …, 2021 - journals.plos.org
Consciousness transiently fades away during deep sleep, more stably under anesthesia,
and sometimes permanently due to brain injury. The development of an index to quantify the …

Perturbation of whole-brain dynamics in silico reveals mechanistic differences between brain states

G Deco, J Cabral, VM Saenger, M Boly, E Tagliazucchi… - Neuroimage, 2018 - Elsevier
Human neuroimaging research has revealed that wakefulness and sleep involve very
different activity patterns. Yet, it is not clear why brain states differ in their dynamical …

[HTML][HTML] A comprehensive neural simulation of slow-wave sleep and highly responsive wakefulness dynamics

JS Goldman, L Kusch, D Aquilue… - Frontiers in …, 2023 - frontiersin.org
Hallmarks of neural dynamics during healthy human brain states span spatial scales from
neuromodulators acting on microscopic ion channels to macroscopic changes in …

[HTML][HTML] Modeling regional changes in dynamic stability during sleep and wakefulness

IP Ipiña, PD Kehoe, M Kringelbach, H Laufs, A Ibañez… - NeuroImage, 2020 - Elsevier
Global brain states are frequently placed within a unidimensional continuum by correlational
studies, ranging from states of deep unconsciousness to ordinary wakefulness. An …

Induction and quantification of excitability changes in human cortical networks

CJ Keller, Y Huang, JL Herrero, ME Fini… - Journal of …, 2018 - Soc Neuroscience
How does human brain stimulation result in lasting changes in cortical excitability?
Uncertainty on this question hinders the development of personalized brain stimulation …

Direct electrical stimulation as an input gate into brain functional networks: principles, advantages and limitations

E Mandonnet, PA Winkler, H Duffau - Acta neurochirurgica, 2010 - Springer
Background While the fundamental and clinical contribution of direct electrical stimulation
(DES) of the brain is now well acknowledged, its advantages and limitations have not been …

[HTML][HTML] Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep

ABA Stevner, D Vidaurre, J Cabral, K Rapuano… - Nature …, 2019 - nature.com
The modern understanding of sleep is based on the classification of sleep into stages
defined by their electroencephalography (EEG) signatures, but the underlying brain …

Selective activation of resting-state networks following focal stimulation in a connectome-based network model of the human brain

A Spiegler, ECA Hansen, C Bernard, AR McIntosh… - eneuro, 2016 - eneuro.org
When the brain is stimulated, for example, by sensory inputs or goal-oriented tasks, the brain
initially responds with activities in specific areas. The subsequent pattern formation of …

[HTML][HTML] Signature of consciousness in brain-wide synchronization patterns of monkey and human fMRI signals

G Hahn, G Zamora-López, L Uhrig, E Tagliazucchi… - NeuroImage, 2021 - Elsevier
During the sleep-wake cycle, the brain undergoes profound dynamical changes, which
manifest subjectively as transitions between conscious experience and unconsciousness …