The genetic changes of hepatoblastoma

H Chen, Q Guan, H Guo, L Miao, Z Zhuo - Frontiers in oncology, 2021 - frontiersin.org
Hepatoblastoma is the most common malignant liver cancer in childhood. The etiology of
hepatoblastoma remains obscure. Hepatoblastoma is closely related to genetic syndromes …

Epigenetics and genetics of hepatoblastoma: linkage and treatment

L Zhu, W Zheng, Q Gao, T Chen, Z Pan, W Cui… - Frontiers in …, 2022 - frontiersin.org
Hepatoblastoma is a malignant embryonal tumor with multiple differentiation modes and is
the clearest liver malignancy in children. However, little is known about genetic and …

Genetics and epigenetics of hepatoblastoma

GE Tomlinson, R Kappler - Pediatric blood & cancer, 2012 - Wiley Online Library
A number of unique genetic features are observed in hepatoblastoma that have provided
insights into the origins of hepatoblastoma. Hallmark cytogenetic changes in …

The genetic and epigenetic landscapes of hepatoblastomas

TFM Aguiar, TN Carneiro, CML da Costa… - Applied Cancer …, 2017 - Springer
Primary liver cancers are rare in children, and the most common type is hepatoblastoma
(HB), an embryonal tumor with histological features that resemble different stages of liver …

Whole-genome sequencing and RNA sequencing analysis reveals novel risk genes and differential expression patterns in hepatoblastoma

W Wang, N Zhang, L Chen, X Zhao, Y Shan, F Yang… - Gene, 2024 - Elsevier
Hepatoblastoma (HB) is an uncommon malignant liver cancer primarily affecting infants and
children, characterized by the presence of tissue that resembling fetal hepatocytes, mature …

Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications

J Carrillo-Reixach, L Torrens, M Simon-Coma… - Journal of …, 2020 - Elsevier
Background & Aims Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the
predominant pediatric liver cancer, with limited therapeutic options for patients with …

[引用][C] Unravelling the genetics of hepatoblastoma: few mutations, what else?

MA Buendia - Journal of Hepatology, 2014 - journal-of-hepatology.eu
Among different types of primary liver cancer, hepatoblastoma (HB) has singular clinical,
pathological and biological characteristics that deserve closer attention. This rare paediatric …

[PDF][PDF] Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups

P Sumazin, Y Chen, LR Treviño, SF Sarabia… - …, 2017 - Wiley Online Library
Despite being the most common liver cancer in children, hepatoblastoma (HB) is a rare
neoplasm. Consequently, few pretreatment tumors have been molecularly profiled, and …

Genetic changes in hepatoblastoma

SF Ding, NE Michail, NA Habib - Journal of hepatology, 1994 - Elsevier
Hepatoblastoma is a rare cancer, but it is the most common primary malignant hepatic
tumour in childhood, accounting for 71-75/,, of liver cancers (1, 2). The environmental risk …

Unraveling the genetic architecture of hepatoblastoma risk: birth defects and increased burden of germline damaging variants in gastrointestinal/renal cancer …

T Aguiar, A Teixeira, MO Scliar… - Frontiers in …, 2022 - frontiersin.org
The ultrarare hepatoblastoma (HB) is the most common pediatric liver cancer. HB risk is
related to a few rare syndromes, and the molecular bases remain elusive for most cases. We …