[HTML][HTML] Alpha-synuclein contribution to neuronal and glial damage in Parkinson's disease
K Saramowicz, N Siwecka, G Galita… - International journal of …, 2023 - mdpi.com
Parkinson's disease (PD) is a complex neurodegenerative disease characterized by the
progressive loss of dopaminergic neurons in the substantia nigra and the widespread …
progressive loss of dopaminergic neurons in the substantia nigra and the widespread …
Alpha-synuclein: The interplay of pathology, neuroinflammation, and environmental factors in Parkinson's disease
S He, S Zhong, G Liu, J Yang - Neurodegenerative Diseases, 2021 - karger.com
Background: Parkinson's disease (PD) is a multifactorial, chronic, and progressive
neurodegenerative disease. α-Synuclein (α-syn), which is the main protein component of …
neurodegenerative disease. α-Synuclein (α-syn), which is the main protein component of …
Effects of α-synuclein-associated post-translational modifications in Parkinson's disease
S He, F Wang, KKL Yung, S Zhang… - ACS chemical …, 2021 - ACS Publications
α-Synuclein (α-syn), a small highly conserved presynaptic protein containing 140 amino
acids, is thought to be the main pathological hallmark in related neurodegenerative …
acids, is thought to be the main pathological hallmark in related neurodegenerative …
From Synaptic Physiology to Synaptic Pathology: The Enigma of α-Synuclein
K Nordengen, C Morland - International journal of molecular sciences, 2024 - mdpi.com
Alpha-synuclein (α-syn) has gained significant attention due to its involvement in
neurodegenerative diseases, particularly Parkinson's disease. However, its normal function …
neurodegenerative diseases, particularly Parkinson's disease. However, its normal function …
Ignored avenues in alpha-synuclein associated proteopathy
Alpha-Synuclein (αSyn) is a 14 kDa pre-synaptic protein predominantly expressed in
various regions of brain comprising neocortex, hippocampus, striatum, thalamus and …
various regions of brain comprising neocortex, hippocampus, striatum, thalamus and …
[HTML][HTML] Pathogenesis of α-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective
S Yi, L Wang, H Wang, MS Ho, S Zhang - International Journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …
[HTML][HTML] The role of α-synuclein oligomers in Parkinson's disease
X Du, X Xie, R Liu - International journal of molecular sciences, 2020 - mdpi.com
α-synuclein (α-syn) is a protein associated with the pathogenesis of Parkinson's disease
(PD), the second most common neurodegeneration disease with no effective treatment …
(PD), the second most common neurodegeneration disease with no effective treatment …
[HTML][HTML] The protein alpha-synuclein: its normal role (in neurons) and its role in disease
RG Perez - Frontiers in Neuroscience, 2020 - frontiersin.org
The protein alpha-Synuclein (aSyn) is highly-studied due to its role in Parkinson's disease
(PD) and its accrual as the major protein component of Lewy bodies/Lewy neurites …
(PD) and its accrual as the major protein component of Lewy bodies/Lewy neurites …
[HTML][HTML] “Janus-Faced” α-synuclein: role in Parkinson's disease
Parkinson's disease (PD) is a pathological condition characterized by the aggregation and
the resultant presence of intraneuronal inclusions termed Lewy bodies (LBs) and Lewy …
the resultant presence of intraneuronal inclusions termed Lewy bodies (LBs) and Lewy …
[HTML][HTML] Alpha-synuclein: from early synaptic dysfunction to neurodegeneration
V Ghiglieri, V Calabrese, P Calabresi - Frontiers in Neurology, 2018 - frontiersin.org
Over the last two decades, many experimental and clinical studies have provided solid
evidence that alpha-synuclein (α-syn), a small, natively unfolded protein, is closely related to …
evidence that alpha-synuclein (α-syn), a small, natively unfolded protein, is closely related to …