[HTML][HTML] Aflatoxin biosynthesis, genetic regulation, toxicity, and control strategies: A review

R Khan, FM Ghazali, NA Mahyudin, NIP Samsudin - Journal of Fungi, 2021 - mdpi.com
Aflatoxins (AFs) are highly toxic and cancer-causing compounds, predominantly synthesized
by the Aspergillus species. AFs biosynthesis is a lengthy process that requires as minimum …

[HTML][HTML] Updates on the Functions and Molecular Mechanisms of the Genes Involved in Aspergillus flavus Development and Biosynthesis of Aflatoxins

E Tumukunde, R Xie, S Wang - Journal of Fungi, 2021 - mdpi.com
Aspergillus flavus (A. flavus) is a ubiquitous and opportunistic fungal pathogen that causes
invasive and non-invasive aspergillosis in humans and animals. This fungus is also capable …

[HTML][HTML] Aflatoxin biosynthesis and genetic regulation: A review

I Caceres, A Al Khoury, R El Khoury, S Lorber… - Toxins, 2020 - mdpi.com
The study of fungal species evolved radically with the development of molecular techniques
and produced new evidence to understand specific fungal mechanisms such as the …

Unlocking the Secrets Behind Secondary Metabolism: A Review of Aspergillus flavus from Pathogenicity to Functional Genomics

KA Scheidegger, GA Payne - Journal of Toxicology: Toxin Reviews, 2003 - Taylor & Francis
Aspergillus flavus has received a considerable amount of attention due to its ability to
produce aflatoxin, a secondary metabolite that is both immunosuppressive and carcinogenic …

Sequence comparison of aflR from different Aspergillus species provides evidence for variability in regulation of aflatoxin production

KC Ehrlich, BG Montalbano, PJ Cotty - Fungal Genetics and Biology, 2003 - Elsevier
Aflatoxin contamination of foods and feeds is a world-wide agricultural problem. Aflatoxin
production requires expression of the biosynthetic pathway regulatory gene, aflR, which …

Understanding the genetics of regulation of aflatoxin production and Aspergillus flavus development

D Bhatnagar, JW Cary, K Ehrlich, J Yu, TE Cleveland - Mycopathologia, 2006 - Springer
Aflatoxins are polyketide-derived, toxic, and carcinogenic secondary metabolites produced
primarily by two fungal species, Aspergillus flavus and A. parasiticus, on crops such as corn …

The aflatoxin pathway regulator AflR induces gene transcription inside and outside of the aflatoxin biosynthetic cluster

MS Price, J Yu, WC Nierman, HS Kim… - FEMS Microbiology …, 2006 - academic.oup.com
abstract Aflatoxin contamination of food and feed is a major concern due to the carcinogenic
properties of this mycotoxin. Previous studies using classical approaches have identified a …

Aflatoxin conducive and non-conducive growth conditions reveal new gene associations with aflatoxin production

MS Price, SB Conners, S Tachdjian, RM Kelly… - Fungal Genetics and …, 2005 - Elsevier
Research on aflatoxin (AF) production has traditionally focused on defining the AF
biosynthetic pathway with the goal of identifying potential targets for intervention. To …

Cloning of the afl-2 gene involved in aflatoxin biosynthesis from Aspergillus flavus

GA Payne, GJ Nystrom, D Bhatnagar… - Applied and …, 1993 - Am Soc Microbiol
Aflatoxins are extremely potent carcinogens produced by Aspergillus flavus and Aspergillus
parasiticus. Cloning of genes in the aflatoxin pathway provides a specific approach to …

The Aspergillus parasiticus protein AFLJ interacts with the aflatoxin pathway-specific regulator AFLR

PK Chang - Molecular Genetics and Genomics, 2003 - Springer
The Aspergillus parasiticus aflJ gene, which is located in the aflatoxin biosynthetic gene
cluster and is transcribed divergently from the aflatoxin pathway regulatory gene aflR …