Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a Ca2+
permeable, non-selective cation channel that is found primarily in sensory nerve fibres …

Osteoarthritis (OA) is a debilitating joint disorder that affects millions of people worldwide.
Despite its prevalence, our understanding of the underlying mechanisms remains …

This study aims to determine the molecular mechanisms and analgesic effects of transient
receptor potential vanilloid 1 (TRPV1) in the treatments of osteoarthritis (OA) and rheumatoid …

Rheumatoid arthritis (RA) is characterized by the augment of vascular permeability,
increased inflammatory cells infiltration, dysregulated immune cells activation, pannus …

Abstract TRPV1 is a Ca2+-permeable channel studied mostly as a pain receptor in sensory
neurons. However, its role in other cell types is poorly understood. Here we found that …

Little is known about the regulation of arthritis severity and joint damage in rheumatoid
arthritis (RA). Fibroblast-like synoviocytes (FLS) have a central role in joint damage and …

TRPV1 and TRPA1 channels in inflammatory pain: elucidating mechanisms | CiNii Research
CiNii 国立情報学研究所 学術情報ナビゲータ[サイニィ] 詳細へ移動 検索フォームへ移動 論文 …

The nervous and immune systems are crucial in fighting infections and inflammation and in
maintaining immune homeostasis. The immune and nervous systems are independent, yet …

In the 1990s, the identification of a non-selective ion channel, especially responsive to
capsaicin, revolutionized the studies of somatosensation and pain that were to follow. The …

Transient receptor potential vanilloid (TRPV) 4 belongs to the TRPV subfamily of TRP ion
channels. TRPV4 channels play a critical role in chondrocytes and thus TRPV4 is an …