Complex multicellular organisms, such as mammals, express two complete sets of
chromosomes per nucleus, combining the genetic material of both parents. However …

Mammalian evolution entailed multiple innovations in gene regulation, including the
emergence of genomic imprinting, an epigenetic regulation leading to the preferential …

Genes that are subject to genomic imprinting in mammals are preferentially expressed from
a single parental allele. This imprinted expression of a small number of genes is crucial for …

In a small fraction of mammalian genes—at present estimated at less than 1% of the total—
one of the two alleles that is inherited by the offspring is partially or completely switched off …

Genomic imprinting in gametogenesis marks a subset of mammalian genes for parent‐of‐
origin‐dependent monoallelic expression in the offspring. Embryological and classical …

Genomic imprinting is an epigenetic phenomenon that results in monoallelic gene
expression according to parental origin. It has long been established that imprinted genes …

Genomic imprinting is an epigenetic process that restricts gene expression to either the
maternally or paternally inherited allele,. Many theories have been proposed to explain its …

The emerging awareness of the contribution of epigenetic processes to genome function in
health and disease is underpinned by decades of research in model systems. In particular …

Genomic imprinting results in parent-of-origin-dependent, monoallelic expression of genes.
The functional haploid state of these genes has far-reaching consequences. Not only has …

In mammals, most somatic cells contain two copies of each autosomal gene, one inherited
from each parent. When a gene is expressed, both parental alleles are usually transcribed …