Background Ischemia/reperfusion (I/R) injury causes overproduction of reactive oxygen
species, which are the major culprits of oxidative stress that leads to inflammation …

Hepatic ischemia-reperfusion injury (IRI) remains a major concern in liver transplantation
and resection, despite continuing efforts to prevent it. Accumulating evidence suggests that …

Acute kidney injury (AKI) is a common pathological process that is globally associated with a
high morbidity and mortality rate. The underlying AKI mechanisms include over-produced …

Background Unconjugated bilirubin (UCB), an endogenous antioxidant, may protect the
heart against ischemia–reperfusion (I–R) injury. However, the 'cardioprotective'potential of …

Myocardial ischemia-reperfusion (IR) injury limits the therapeutic effect of early reperfusion
therapy for acute myocardial infarction (AMI), in which the recruitment of inflammatory …

Acute pancreatitis (AP) is a sudden inflammatory reaction, caused by the activation of
pancreatic enzymes in the pancreas, and in severe cases can lead to systemic inflammation …

Aim There is an unmet need to develop an innovative cardioprotective modality for acute
myocardial infarction (AMI), for which the effectiveness of interventional reperfusion therapy …

Acute lung injury (ALI) remains one of the most common complications of sepsis. Although
many potential effective pharmacologic and ventilatory treatment strategies have been …

Background There is an unmet need to develop an innovative cardioprotective modality for
acute myocardial infarction, for which interventional reperfusion therapy is hampered by …

Our previous works have shown that tanshinone IIA inhibited maladaptive extracellular
matrix remodeling in cardiac fibroblasts implicating its potential role in treating of pathologic …