The role of host genetics in the immune response to SARS‐CoV‐2 and COVID‐19 susceptibility and severity

IG Ovsyannikova, IH Haralambieva… - Immunological …, 2020 - Wiley Online Library
This article provides a review of studies evaluating the role of host (and viral) genetics
(including variation in HLA genes) in the immune response to coronaviruses, as well as the …

HLA variation and SARS-CoV-2 specific antibody response

D Wolday, CYJ Fung, G Morgan, S Casalino… - Viruses, 2023 - mdpi.com
Differences in SARS-CoV-2-specific immune responses have been observed between
individuals following natural infection or vaccination. In addition to already known factors …

Deciphering the role of host genetics in susceptibility to severe COVID-19

ME Carter-Timofte, SE Jørgensen, MR Freytag… - Frontiers in …, 2020 - frontiersin.org
Coronavirus disease-19 (COVID-19) describes a set of symptoms that develop following
infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whilst …

Association of HLA gene polymorphism with susceptibility, severity, and mortality of COVID‐19: a systematic review

P Deb, K Zannat, S Talukder, AH Bhuiyan, MSA Jilani… - Hla, 2022 - Wiley Online Library
HLA is crucial for appropriate immune responses in several viral infections, as well as in
severe acute respiratory syndrome coronavirus‐2 (SARS CoV‐2). The unpredictable nature …

The role of host genetics in susceptibility to severe viral infections in humans and insights into host genetics of severe COVID-19: A systematic review

A Elhabyan, S Elyaacoub, E Sanad, A Abukhadra… - Virus research, 2020 - Elsevier
Background Susceptibility to severe viral infections was reported to be associated with
genetic variants in immune response genes using case reports and GWAS studies. SARS …

Human leukocyte antigen susceptibility map for severe acute respiratory syndrome coronavirus 2

A Nguyen, JK David, SK Maden, MA Wood… - Journal of …, 2020 - Am Soc Microbiol
Genetic variability across the three major histocompatibility complex (MHC) class I genes
(human leukocyte antigen A [HLA-A],-B, and-C genes) may affect susceptibility to and …

Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature

F Migliorini, E Torsiello, F Spiezia, F Oliva… - European Journal of …, 2021 - Springer
The COVID-19 pandemic has markedly impacted on cultural, political, and economic
structures all over the world. Several aspects of its pathogenesis and related clinical …

The influence of HLA genotype on the severity of COVID‐19 infection

DJ Langton, SC Bourke, BA Lie, G Reiff, S Natu… - Hla, 2021 - Wiley Online Library
The impact of COVID‐19 varies markedly, not only between individual patients but also
between different populations. We hypothesised that differences in HLA genes might …

Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis

E Di Maria, A Latini, P Borgiani, G Novelli - Human genomics, 2020 - Springer
The COVID-19 pandemic has strengthened the interest in the biological mechanisms
underlying the complex interplay between infectious agents and the human host. The …

The COVID-19 host genetics initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic

COVID-19 Host Genetics Initiative aganna … - European Journal of …, 2020 - nature.com
The COVID-19 pandemic is a global crisis creating severe disruptions across the economy
and health system. Insights into how to better understand and treat COVID-19 are …