Chromatin plays critical roles in regulating transcription. It needs to be accessible to allow
the binding of specific regulators such as transcription factors and other gene regulatory …

Regulation of cellular protein homeostasis in response to environmental challenges such as
nutrient availability is essential for maintaining cell function and viability. The surrounding …

Chromatin regulation is an important gene expression/regulation system, but little is known
about how it affects nitrogen metabolism in Saccharomyces cerevisiae. A previous study …

Eukaryotes are constantly fine-tuning their gene expression programs in response to the
demands of the environment and the availability of nutrients. Such dynamic regulation of the …

Covalent histone post-translational modifications such as acetylation, methylation,
phosphorylation, and ubiquitylation play pivotal roles in regulating many cellular processes …

There is a complex regulatory network of nitrogen metabolism in Saccharomyces cerevisiae,
and many details of this regulatory network have not been revealed. This study explored the …

NAD+ is a cellular redox cofactor involved in many essential processes. The regulation of
NAD+ metabolism and the signaling networks reciprocally interacting with NAD+-producing …

Transcription through noncoding regions of the genome is pervasive. How these
transcription events regulate gene expression remains poorly understood. Here, we report …

Multiple regulatory mechanisms work to ensure that eukaryotic transcription maintains
mRNA pools and subsequent protein synthesis. When errors in transcription occur …

FACT is a histone chaperone that can destabilize or assemble nucleosomes. Acetylation of
histone H3-K56 weakens a histone: DNA contact that is central to FACT activity, suggesting …