[HTML][HTML] Biphalin—A Potent Opioid Agonist—As a Panacea for Opioid System-Dependent Pathophysiological Diseases?
P Redkiewicz, J Dyniewicz, A Misicka - International Journal of Molecular …, 2021 - mdpi.com
Biphalin, one of the opioid agonists, is a dimeric analog of enkephalin with a high affinity for
opioid receptors. Opioid receptors are widespread in the central nervous system and in …
opioid receptors. Opioid receptors are widespread in the central nervous system and in …
Structure-activity relationships of biphalin analogs and their biological evaluation on opioid receptors
F Feliciani, F Pinnen, A Stefanucci… - Mini reviews in …, 2013 - ingentaconnect.com
Biphalin (Tyr-D-Ala-Gly-Phe-NH-NH<-Phe<-Gly<-D-Ala<-Tyr) is an opioid octapeptide with a
dimeric structure based on two identical pharmacophore portions, derived from enkephalins …
dimeric structure based on two identical pharmacophore portions, derived from enkephalins …
Biological Active Analogues of the Opioid Peptide Biphalin: Mixed α/β3-Peptides
A Mollica, F Pinnen, R Costante… - Journal of medicinal …, 2013 - ACS Publications
Natural residues of the dimeric opioid peptide Biphalin were replaced by the corresponding
homo-β3 amino acids. The derivative 1 containing hβ3 Phe in place of Phe showed good μ …
homo-β3 amino acids. The derivative 1 containing hβ3 Phe in place of Phe showed good μ …
Analgesic activity of a novel bivalent opioid peptide compared to morphine via different routes of administration
BS Silbert, AW Lipkowski, MS Cepeda, SK Szyfelbein… - Agents and actions, 1991 - Springer
A novel bivalent opioid tetrapeptide, biphalin (Tyr-d-Ala-Gly-Phe-NH) 2, was synthesized
based on structure-activity relationships. The analgesic activity of biphalin was assessed in …
based on structure-activity relationships. The analgesic activity of biphalin was assessed in …
Biphalin analogs containing β3-Homo-amino acids at the 4, 4′ positions: Synthesis and opioid activity profiles
O Frączak, A Lasota, P Kosson, A Leśniak… - Peptides, 2015 - Elsevier
Biphalin, a synthetic opioid octapeptide with a palindromic sequence has high analgesic
activity. Biphalin displays a strong affinity for μ and δ-opioid receptors, and a significant to κ …
activity. Biphalin displays a strong affinity for μ and δ-opioid receptors, and a significant to κ …
Synthesis and biological activity of the first cyclic biphalin analogues
Biphalin is a linear octapeptide with strong opioid activity. Its structure is based on two
identical sequences derived from enkephalins joined C-terminal to C-terminal by an …
identical sequences derived from enkephalins joined C-terminal to C-terminal by an …
Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers
Biphalin is a potent opioid peptide agonist, with a palandromic structure, composed of two
enkephalin-like active fragments connected tail to tail by a hydrazine linker (Tyr-D-Ala-Gly …
enkephalin-like active fragments connected tail to tail by a hydrazine linker (Tyr-D-Ala-Gly …
Synthesis and pharmacological properties of a new fluorescent opioid peptide analog
M Lukowiak, P Kosson, WE Hennink… - Pharmacological …, 2009 - Springer
Biphalin, is a palindromic peptide [(Tyr-D-Ala-Gly-Phe-NH-) 2] in which two opioid
pharmacophores are connected “tail-to-tail.” This peptide displays a broad affinity for all …
pharmacophores are connected “tail-to-tail.” This peptide displays a broad affinity for all …
Characterization and analysis of biphalin: an opioid peptide with a palindromic sequence
K Hettiarachchi, S Ridge, DW Thomas… - The Journal of …, 2001 - Wiley Online Library
Among the many opioid peptides developed to date as nonaddictive analgesics, biphalin
has exhibited extraordinary high potency and many other desirable characteristics. Biphalin …
has exhibited extraordinary high potency and many other desirable characteristics. Biphalin …
The Biological Consequences of Replacing d‐Ala in Biphalin with Amphiphilic α‐Alkylserines
O Frączak, A Lasota, A Leśniak… - Chemical Biology & …, 2014 - Wiley Online Library
Biphalin, a synthetic opioid peptide with a broad affinity for all opioid receptors (δ, μ, and κ)
and high antinociceptive activity, has been under extensive study as a potential analgesic …
and high antinociceptive activity, has been under extensive study as a potential analgesic …