Micronization of cilostazol using supercritical antisolvent (SAS) process: effect of process parameters

MS Kim, S Lee, JS Park, JS Woo, SJ Hwang - Powder Technology, 2007 - Elsevier
The aim of this study was to improve dissolution rate of poorly water-soluble drug, cilostazol,
using supercritical antisolvent (SAS) process. The effect of process variables, such as …

Enhancement of wettability and dissolution properties of cilostazol using the supercritical antisolvent process: effect of various additives

MS Kim, JS Kim, SJ Hwang - Chemical and Pharmaceutical Bulletin, 2010 - jstage.jst.go.jp
The aim of this study was to improve wettability and dissolution rate of a poorly water-soluble
drug, cilostazol, using the supercritical antisolvent (SAS) process. The solid state of particles …

Crystallization of micro particles of sulindac using rapid expansion of supercritical solution

AZ Hezave, F Esmaeilzadeh - Journal of Crystal Growth, 2010 - Elsevier
In pharmaceutical industry, many drugs exhibit poor solubility in biological fluid. Solubility of
drugs affects on the rate of dissolution and bioavailability in biological fluids. The …

Recrystallization and micronization of sulfathiazole by applying the supercritical antisolvent technology

YM Chen, M Tang, YP Chen - Chemical Engineering Journal, 2010 - Elsevier
Recrystallization and micronization for an antibacterial active pharmaceutical ingredient
(API), sulfathiazole, was investigated in this study using the supercritical antisolvent (SAS) …

Micronization of sulfamethoxazole using the supercritical anti-solvent process

YP Chang, M Tang, YP Chen - Journal of materials science, 2008 - Springer
Micronization of an antibiotic compound sulfamethoxazole was investigated in this study
using the supercritical anti-solvent (SAS) precipitation method. The results from either the …

Drug recrystallization using supercritical anti-solvent (SAS) process with impinging jets: Effect of process parameters

S Careno, O Boutin, E Badens - Journal of Crystal Growth, 2012 - Elsevier
The aim of this study is to improve mixing in supercritical anti-solvent process (SAS) with
impinging jets in order to form finer particles of sulfathiazole, a poorly water-soluble drug …

Fabrication of micron level particles of amoxicillin by rapid expansion of supercritical solution

AZ Hezave, F Esmaeilzadeh - Journal of dispersion science and …, 2012 - Taylor & Francis
In this study, the rapid expansion of supercritical solution (RESS) process was used to
precipitate fine solid particles of amoxiccilin where supercritical carbon dioxide was used as …

Particle preparation of pharmaceutical compounds using supercritical antisolvent process: current status and future perspectives

R Kumar, AK Thakur, G Kali, KC Pitchaiah… - Drug Delivery and …, 2023 - Springer
The low aqueous solubility and subsequently slow dissolution rate, as well as the poor
bioavailability of several active pharmaceutical ingredients (APIs), are major challenges in …

Micronization of drug particles via RESS process

AZ Hezave, F Esmaeilzadeh - The Journal of Supercritical Fluids, 2010 - Elsevier
The rapid expansion of a supercritical solution (RESS) process is an attractive technology
for the production of small, uniform and solvent-free particles of low vapour pressure solutes …

[HTML][HTML] Effect of process parameters on the recrystallization and size control of puerarin using the supercritical fluid antisolvent process

Y Li, Y Yu, H Wang, F Zhao - asian journal of pharmaceutical sciences, 2016 - Elsevier
The purpose of this study was to investigate the influence of the supercritical CO 2
processing on the particle size and morphology of puerarin crystals. The process …