Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

Major depression disorder (MDD) is a debilitating mental illness with significant morbidity
and mortality. Despite the growing number of studies that have emerged, the precise …

Clinical depressive disorders are complex in presentation, dissimilar in origins and course,
and often pleomorphic in character. An adequate understanding of their origins, biological …

Simple tests for antidepressant‐like activity, such as 5‐HTP‐induced syndrome or reserpine‐
induced hypomotility, are often mechanism‐based tests, pharmacologically specific for …

Animal models of depression are dence between drug actions in the most hrquently
encountered model and in the clinic), face within the pharmaceutical in- validity …

Animal models of depression are certainly needed but the question in the title has been
raised owing to the controversies in the interpretation of the readout in a number of tests, to …

The most familiar usage of animal models of depression is as antidepressant screening tests
Paul Willner reviews their usage in a different context—as simulations of depression. The …

Are there appropiate rodent models for human depressive disorders? A model that targets a
core aspect of depression can become a helpful tool in the analysis of the causes, genetic or …

Major depressive disorder is a common, complex, and potentially life-threatening mental
disorder that imposes a severe social and economic burden worldwide. Over the years …

Depression is a chronic, recurring and potentially life-threatening illness that affects up to
20% of the population across the world. Despite its prevalence and considerable impact on …