SARS-CoV-2 Spike Proteins and Cell–Cell Communication Induce P-Selectin and Markers of Endothelial Injury, NETosis, and Inflammation in Human Lung …

B Bhargavan, GD Kanmogne - International journal of molecular sciences, 2023 - mdpi.com
COVID-19 progression often involves severe lung injury, inflammation, coagulopathy, and
leukocyte infiltration into pulmonary tissues. The pathogenesis of these complications is …

SARS-CoV-2 spike proteins and cell–cell communication inhibits TFPI and induces thrombogenic factors in human lung microvascular endothelial cells and …

B Bhargavan, GD Kanmogne - International journal of molecular sciences, 2022 - mdpi.com
In SARS-CoV-2-infected humans, disease progression is often associated with acute
respiratory distress syndrome involving severe lung injury, coagulopathy, and thrombosis of …

SARS-CoV-2 spike protein 1 activates microvascular endothelial cells and complement system leading to platelet aggregation

L Perico, M Morigi, M Galbusera, A Pezzotta… - Frontiers in …, 2022 - frontiersin.org
Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus
disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability …

Endothelial cell activation by SARS-CoV-2 spike S1 protein: a crosstalk between endothelium and innate immune cells

BM Rotoli, A Barilli, R Visigalli, F Ferrari, V Dall'Asta - Biomedicines, 2021 - mdpi.com
Background. Emerging evidences suggest that in severe COVID-19, multi-organ failure is
associated with a hyperinflammatory state (the so-called “cytokine storm”) in combination …

SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells

A Villacampa, E Alfaro, C Morales… - Cell Communication and …, 2024 - Springer
Background Hyperinflammation, hypercoagulation and endothelial injury are major findings
in acute and post-COVID-19. The SARS-CoV-2 S protein has been detected as an isolated …

Pathogenic basis of thromboinflammation and endothelial injury in COVID-19: current findings and therapeutic implications

Y Higashikuni, W Liu, T Obana, M Sata - International Journal of …, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has become a global pandemic with a great impact on social …

SARS-CoV-2 and the spike protein in endotheliopathy

L Perico, A Benigni, G Remuzzi - Trends in Microbiology, 2024 - cell.com
Abstract SARS-CoV-2, the causative agent of COVID-19, primarily affects the epithelial
compartment in the upper and lower airways. There is evidence that the microvasculature in …

Covid-19: the rollercoaster of fibrin (ogen), d-dimer, von willebrand factor, p-selectin and their interactions with endothelial cells, platelets and erythrocytes

C Grobler, SC Maphumulo, LM Grobbelaar… - International journal of …, 2020 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), also known as coronavirus
disease 2019 (COVID-19)-induced infection, is strongly associated with various …

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

S Zhang, Y Liu, X Wang, L Yang, H Li, Y Wang… - Journal of hematology & …, 2020 - Springer
Background Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic
state that places them at a dramatically increased lethal risk. Although platelet activation is …

Thrombotic mechanism involving platelet activation, hypercoagulability and hypofibrinolysis in coronavirus disease 2019

H Wada, K Shiraki, H Shimpo, M Shimaoka… - International Journal of …, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19) has spread, with thrombotic complications being
increasingly frequently reported. Although thrombosis is frequently complicated in septic …