Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …

Iron is an essential nutrient for bacterial growth, replication, and metabolism. Humans store
iron bound to various proteins such as hemoglobin, haptoglobin, transferrin, ferritin, and …

Iron is a versatile redox-active catalyst and a required cofactor within a diverse array of
biological processes. To almost all organisms, iron is both essential and potentially toxic …

Siderophores are biosynthetically produced and secreted by many bacteria, yeasts, fungi
and plants, to scavenge for ferric iron (Fe 3+). They are selective iron-chelators that have an …

Bacteria secrete small molecules known as siderophores to acquire iron from their
surroundings. For over 60 years, investigations into the bioinorganic chemistry of these …

Iron is a transition metal utilized by nearly all forms of life for essential cellular processes,
such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the …

Bacteria are able to survive in low-iron environments by sequestering this metal ion from
iron-containing proteins and other biomolecules such as transferrin, lactoferrin, heme …

Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of
essential metal ions, in particular iron, which leads to “nutritional immunity”. However …

Pathogenic microbes rapidly develop resistance to antibiotics. To keep ahead in the
“microbial war”, extensive interdisciplinary research is needed. A primary cause of drug …

Cells growing in aerobic environments have developed intricate strategies to overcome the
scarcity of iron, an essential nutrient. In Gram‐negative bacteria, high‐affinity iron acquisition …