Behaviours of complex biomolecular systems are often irreducible to the elementary
properties of their individual components. Explanatory and predictive mathematical models …

Highly complex molecular networks, which play fundamental roles in almost all cellular
processes, are known to be dysregulated in a number of diseases, most notably in cancer …

Remarkable progress in genomic research is leading to a complete map of the building
blocks of biology. Knowledge of this map is, in turn, setting the stage for a fundamental …

Biological systems form complex networks of interaction on several scales, ranging from the
molecular to the ecosystem level. On the subcellular scale, interaction between genes and …

The advent of ever more sophisticated molecular manipulation techniques has made it clear
that cellular systems are far more complex and dynamic than previously thought. At the …

Gene regulatory networks have an important role in every process of life, including cell
differentiation, metabolism, the cell cycle and signal transduction. By understanding the …

Genome sequences are now available that enable us to determine the biological
components that make up a cell or an organism. The discipline of systems biology examines …

In order to understand the functioning of organisms on the molecular level, we need to know
which genes are expressed, when and where in the organism, and to which extent. The …

Large‐scale protein signalling networks are useful for exploring complex biochemical
pathways but do not reveal how pathways respond to specific stimuli. Such specificity is …

Abstract Systems biology applies quantitative, mechanistic modelling to study genetic
networks, signal transduction pathways and metabolic networks. Mathematical models of …