TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?

A Kumar, W Abbas, G Herbein - Mediators of inflammation, 2013 - Wiley Online Library
Tumor necrosis factor (TNF) and TNF receptors (TNFR) superfamily members are engaged
in diverse cellular phenomena such as cellular proliferation, morphogenesis, apoptosis …

Targeting TNF and TNF receptor pathway in HIV-1 infection: from immune activation to viral reservoirs

S Pasquereau, A Kumar, G Herbein - Viruses, 2017 - mdpi.com
Several cellular functions such as apoptosis, cellular proliferation, inflammation, and
immune regulation involve the tumor necrosis factor-α (TNF)/TNF receptor (TNFR) pathway …

Is HIV infection a TNF receptor signalling-driven disease?

G Herbein, KA Khan - Trends in immunology, 2008 - cell.com
Recent studies indicate that TNF (tumor necrosis factor) receptor signalling is a key player in
HIV infection. HIV proteins have been shown to target TNF receptor signalling, leading both …

Targeting TNF-alpha in HIV-1 infection

A Kumar, L Coquard, G Herbein - Current Drug Targets, 2016 - ingentaconnect.com
Highly active antiretroviral therapy (HAART) has dramatically extended the lifespan and
quality of life of individuals infected with human immunodeficiency virus type 1 (HIV-1) …

Tumor Necrosis Factor (TNF)–α and TNF Receptors in Viral Pathogenesis

G Herbein, WA O'brien - … of the Society for Experimental Biology …, 2000 - Wiley Online Library
Tumor necrosis factor–α (TNF‐α) and TNF receptors (TNFR) are members of the growing
TNF ligand and receptor families that are involved in immune regulation. The present report …

Membrane tumor necrosis factor (TNF) induced cooperative signaling of TNFR60 and TNFR80 favors induction of cell death rather than virus production in HIV …

JK Lazdins, M Grell, MR Walker… - The Journal of …, 1997 - rupress.org
Tumor necrosis factor (TNF) and lymphotoxin (LT) are highly pleiotropic cytokines that play a
central role in regulating HIV-1 replication. These cytokines express their activities through …

Macrophage signaling in HIV-1 infection

G Herbein, G Gras, KA Khan, W Abbas - Retrovirology, 2010 - Springer
The human immunodeficiency virus-1 (HIV-1) is a member of the lentivirus genus. The virus
does not rely exclusively on the host cell machinery, but also on viral proteins that act as …

Viruses and the TNF-related cytokines, an evolving battle

CA Benedict - Cytokine & growth factor reviews, 2003 - Elsevier
Tumor necrosis factor (TNF)-related cytokines are critical effector molecules in the immune
response to viral pathogens. Engagement of the TNF receptors by their cognate ligands …

[HTML][HTML] T-cell signaling in HIV-1 infection

W Abbas, G Herbein - The open virology journal, 2013 - ncbi.nlm.nih.gov
HIV exploits the T-cell signaling network to gain access to downstream cellular components,
which serves as effective tools to break the cellular barriers. Multiple host factors and their …

Soluble mediators of inflammation in HIV and their implications for therapeutics and vaccine development

SM Keating, ES Jacobs, PJ Norris - Cytokine & growth factor reviews, 2012 - Elsevier
From early in the HIV epidemic it was appreciated that many inflammatory markers such as
neopterin and TNF-α were elevated in patients with AIDS. With the advent of modern …