TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
Tumor necrosis factor (TNF) and TNF receptors (TNFR) superfamily members are engaged
in diverse cellular phenomena such as cellular proliferation, morphogenesis, apoptosis …
in diverse cellular phenomena such as cellular proliferation, morphogenesis, apoptosis …
Targeting TNF and TNF receptor pathway in HIV-1 infection: from immune activation to viral reservoirs
Several cellular functions such as apoptosis, cellular proliferation, inflammation, and
immune regulation involve the tumor necrosis factor-α (TNF)/TNF receptor (TNFR) pathway …
immune regulation involve the tumor necrosis factor-α (TNF)/TNF receptor (TNFR) pathway …
Is HIV infection a TNF receptor signalling-driven disease?
Recent studies indicate that TNF (tumor necrosis factor) receptor signalling is a key player in
HIV infection. HIV proteins have been shown to target TNF receptor signalling, leading both …
HIV infection. HIV proteins have been shown to target TNF receptor signalling, leading both …
Targeting TNF-alpha in HIV-1 infection
Highly active antiretroviral therapy (HAART) has dramatically extended the lifespan and
quality of life of individuals infected with human immunodeficiency virus type 1 (HIV-1) …
quality of life of individuals infected with human immunodeficiency virus type 1 (HIV-1) …
Tumor Necrosis Factor (TNF)–α and TNF Receptors in Viral Pathogenesis
G Herbein, WA O'brien - … of the Society for Experimental Biology …, 2000 - Wiley Online Library
Tumor necrosis factor–α (TNF‐α) and TNF receptors (TNFR) are members of the growing
TNF ligand and receptor families that are involved in immune regulation. The present report …
TNF ligand and receptor families that are involved in immune regulation. The present report …
Membrane tumor necrosis factor (TNF) induced cooperative signaling of TNFR60 and TNFR80 favors induction of cell death rather than virus production in HIV …
JK Lazdins, M Grell, MR Walker… - The Journal of …, 1997 - rupress.org
Tumor necrosis factor (TNF) and lymphotoxin (LT) are highly pleiotropic cytokines that play a
central role in regulating HIV-1 replication. These cytokines express their activities through …
central role in regulating HIV-1 replication. These cytokines express their activities through …
Macrophage signaling in HIV-1 infection
The human immunodeficiency virus-1 (HIV-1) is a member of the lentivirus genus. The virus
does not rely exclusively on the host cell machinery, but also on viral proteins that act as …
does not rely exclusively on the host cell machinery, but also on viral proteins that act as …
Viruses and the TNF-related cytokines, an evolving battle
CA Benedict - Cytokine & growth factor reviews, 2003 - Elsevier
Tumor necrosis factor (TNF)-related cytokines are critical effector molecules in the immune
response to viral pathogens. Engagement of the TNF receptors by their cognate ligands …
response to viral pathogens. Engagement of the TNF receptors by their cognate ligands …
[HTML][HTML] T-cell signaling in HIV-1 infection
W Abbas, G Herbein - The open virology journal, 2013 - ncbi.nlm.nih.gov
HIV exploits the T-cell signaling network to gain access to downstream cellular components,
which serves as effective tools to break the cellular barriers. Multiple host factors and their …
which serves as effective tools to break the cellular barriers. Multiple host factors and their …
Soluble mediators of inflammation in HIV and their implications for therapeutics and vaccine development
From early in the HIV epidemic it was appreciated that many inflammatory markers such as
neopterin and TNF-α were elevated in patients with AIDS. With the advent of modern …
neopterin and TNF-α were elevated in patients with AIDS. With the advent of modern …