Does reduced MHC diversity decrease viability of vertebrate populations?
Loss of genetic variation may render populations more vulnerable to pathogens due to
inbreeding depression and depletion of variation in genes responsible for immunity against …
inbreeding depression and depletion of variation in genes responsible for immunity against …
[HTML][HTML] The importance of immune gene variability (MHC) in evolutionary ecology and conservation
S Sommer - Frontiers in zoology, 2005 - Springer
Genetic studies have typically inferred the effects of human impact by documenting patterns
of genetic differentiation and levels of genetic diversity among potentially isolated …
of genetic differentiation and levels of genetic diversity among potentially isolated …
Sexual selection and the evolutionary dynamics of the major histocompatibility complex
M Jan Ejsmond, J Radwan… - Proceedings of the …, 2014 - royalsocietypublishing.org
The genes of the major histocompatibility complex (MHC) are a key component of the
adaptive immune system and among the most variable loci in the vertebrate genome …
adaptive immune system and among the most variable loci in the vertebrate genome …
[HTML][HTML] The evolutionary ecology of the major histocompatibility complex
SB Piertney, MK Oliver - Heredity, 2006 - nature.com
The major histocompatibility complex (MHC) has become a paradigm for how selection can
act to maintain adaptively important genetic diversity in natural populations. Here, we review …
act to maintain adaptively important genetic diversity in natural populations. Here, we review …
Disentangling the roles of natural selection and genetic drift in shaping variation at MHC immunity genes
The major histocompatibility complex (MHC) forms an integral component of the vertebrate
immune response and, due to strong selection pressures, is one of the most polymorphic …
immune response and, due to strong selection pressures, is one of the most polymorphic …
[HTML][HTML] Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations
The genes of the major histocompatibility complex are the most polymorphic genes in
vertebrates, with more than 1,000 alleles described in human populations. How this …
vertebrates, with more than 1,000 alleles described in human populations. How this …
MHC studies in nonmodel vertebrates: what have we learned about natural selection in 15 years?
L Bernatchez, C Landry - Journal of evolutionary biology, 2003 - academic.oup.com
Elucidating how natural selection promotes local adaptation in interaction with migration,
genetic drift and mutation is a central aim of evolutionary biology. While several conceptual …
genetic drift and mutation is a central aim of evolutionary biology. While several conceptual …
MHC diversity in bottlenecked populations: a simulation model
MJ Ejsmond, J Radwan - Conservation Genetics, 2011 - Springer
The depletion of variation at MHC loci, which play a crucial role in pathogen recognition, has
been postulated to be one of important extinction risk factors for endangered populations …
been postulated to be one of important extinction risk factors for endangered populations …
Speciation accelerated and stabilized by pleiotropic major histocompatibility complex immunogenes
Speciation and the maintenance of recently diverged species has been subject of intense
research in evolutionary biology for decades. Although the concept of ecological speciation …
research in evolutionary biology for decades. Although the concept of ecological speciation …
Long‐term survival of a urodele amphibian despite depleted major histocompatibility complex variation
Depletion of polymorphism at major histocompatibility complex (MHC) genes has been
hypothesized to limit the ability of populations to respond to emerging pathogens, thus …
hypothesized to limit the ability of populations to respond to emerging pathogens, thus …